Slamon D J, deKernion J B, Verma I M, Cline M J
Science. 1984 Apr 20;224(4646):256-62. doi: 10.1126/science.6538699.
Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.
细胞癌基因在一些体外模型系统中与恶性转化的诱导有关，并且在某些脊椎动物物种中可能与体内恶性肿瘤相关。本文描述了对来自54例患者的新鲜人类肿瘤中15种细胞癌基因表达的研究，这些肿瘤代表20种不同的肿瘤类型。在所有检测的肿瘤中，不止一种细胞癌基因具有转录活性。在14例患者中，可以研究同一器官的正常组织和恶性组织。在许多这些患者中，某些癌基因在恶性组织中的转录活性高于正常组织。细胞fes（猫肉瘤）癌基因以前未知在哺乳动物组织中进行转录，现已发现在肺癌和造血系统恶性肿瘤中具有活性。
