慢性气流受限患者的血浆及脂蛋白脂质与载脂蛋白AI、AII和B
Plasma and lipoprotein lipids and apolipoproteins AI, AII and B in patients with chronic airflow limitation.
作者信息
Bolton C H, Mulloy E, Harvey J, Downs L G, Hartog M
机构信息
University Department of Medicine, Bristol Royal Infirmary.
出版信息
J R Soc Med. 1989 Feb;82(2):91-2. doi: 10.1177/014107688908200212.
Plasma and lipoprotein cholesterol and triglycerides, and plasma apolipoproteins AI, AII and B were compared in patients with chronic airflow limitation, and normal controls matched for body mass index. The controls were non-smokers, and free from respiratory disease. High-density lipoprotein (HDL) cholesterol concentration was significantly elevated in the patients, due mainly to a raised HDL2 cholesterol level. HDL triglyceride was significantly lower in the patients. All other lipids were not different from normal. Apolipoprotein AI levels were significantly raised in the patients but other apolipoproteins were unchanged. The changes found may account in part for the fact that patients with chronic airflow limitation have a lower incidence of atherosclerotic heart disease.
对患有慢性气流受限的患者以及体重指数匹配的正常对照者的血浆和脂蛋白胆固醇、甘油三酯，以及血浆载脂蛋白AI、AII和B进行了比较。对照组为非吸烟者，且无呼吸系统疾病。患者的高密度脂蛋白（HDL）胆固醇浓度显著升高，主要是由于HDL2胆固醇水平升高。患者的HDL甘油三酯显著降低。所有其他脂质与正常情况无差异。患者的载脂蛋白AI水平显著升高，但其他载脂蛋白未发生变化。所发现的这些变化可能部分解释了慢性气流受限患者动脉粥样硬化性心脏病发病率较低的原因。
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