Wilson Bryan A, Marshall Allyson C, Alzayadneh Ebaa M, Chappell Mark C
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina
Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R487-9. doi: 10.1152/ajpregu.00177.2014. Epub 2014 Jun 18.
The kidney is a key target organ for bioactive components of the renin-angiotensin system (RAS); however, various renal cells such as the tubular epithelium contain an intrinsic RAS. The renal RAS can be functionally divided into ANG II-AT1 receptor and ANG-(1-7)-AT7/Mas receptor arms that functionally oppose one another. The current review considers both extracellular and intracellular pathways that potentially govern the formation and metabolism of angiotensin peptides within the renal proximal tubules.
肾脏是肾素-血管紧张素系统（RAS）生物活性成分的关键靶器官；然而，各种肾细胞，如肾小管上皮细胞，都含有内在的RAS。肾RAS在功能上可分为血管紧张素II-1型受体（ANG II-AT1 receptor）和血管紧张素-(1-7)-Mas受体（ANG-(1-7)-AT7/Mas receptor）两条相互拮抗的途径。本综述探讨了可能调控肾近端小管内血管紧张素肽形成和代谢的细胞外和细胞内途径。
