肾脏内血管紧张素加工处理的来龙去脉。
The ins and outs of angiotensin processing within the kidney.
作者信息
Wilson Bryan A, Marshall Allyson C, Alzayadneh Ebaa M, Chappell Mark C
机构信息
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina
出版信息
Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R487-9. doi: 10.1152/ajpregu.00177.2014. Epub 2014 Jun 18.
Abstract
The kidney is a key target organ for bioactive components of the renin-angiotensin system (RAS); however, various renal cells such as the tubular epithelium contain an intrinsic RAS. The renal RAS can be functionally divided into ANG II-AT1 receptor and ANG-(1-7)-AT7/Mas receptor arms that functionally oppose one another. The current review considers both extracellular and intracellular pathways that potentially govern the formation and metabolism of angiotensin peptides within the renal proximal tubules.
摘要
肾脏是肾素-血管紧张素系统（RAS）生物活性成分的关键靶器官；然而，各种肾细胞，如肾小管上皮细胞，都含有内在的RAS。肾RAS在功能上可分为血管紧张素II-1型受体（ANG II-AT1 receptor）和血管紧张素-(1-7)-Mas受体（ANG-(1-7)-AT7/Mas receptor）两条相互拮抗的途径。本综述探讨了可能调控肾近端小管内血管紧张素肽形成和代谢的细胞外和细胞内途径。
相似文献
1
The ins and outs of angiotensin processing within the kidney.肾脏内血管紧张素加工处理的来龙去脉。
Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R487-9. doi: 10.1152/ajpregu.00177.2014. Epub 2014 Jun 18.
2
Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II.绵羊肾近端小管、尿液和血清中的血管紧张素代谢：血管紧张素 II 依赖 ACE2 加工的证据
Am J Physiol Renal Physiol. 2007 Jan;292(1):F82-91. doi: 10.1152/ajprenal.00139.2006. Epub 2006 Aug 8.
3
Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats.在 mRen2.Lewis 大鼠血压和肾素-血管紧张素系统的调节中，AT(1) 阻断占主导地位，而 mas 介导的血管紧张素-(1-7) 机制则处于次要地位。
Am J Hypertens. 2013 May;26(5):583-90. doi: 10.1093/ajh/hps090. Epub 2013 Mar 4.
4
Renin-angiotensin system revisited.再探肾素-血管紧张素系统。
J Intern Med. 2008 Sep;264(3):224-36. doi: 10.1111/j.1365-2796.2008.01981.x.
5
Pathophysiological role of the renin-angiotensin system on erectile dysfunction.肾素-血管紧张素系统在勃起功能障碍中的病理生理作用。
Eur J Clin Invest. 2013 Sep;43(9):978-85. doi: 10.1111/eci.12117. Epub 2013 Jun 12.
6
Role of renin-angiotensin system and metabolites of angiotensin in the mechanism of gastric mucosal protection.肾素-血管紧张素系统及血管紧张素代谢产物在胃黏膜保护机制中的作用
Curr Opin Pharmacol. 2014 Dec;19:90-8. doi: 10.1016/j.coph.2014.08.007. Epub 2014 Sep 18.
7
Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System.体育锻炼与肾素血管紧张素系统的ACE2-血管紧张素-（1-7）-Mas受体轴
Protein Pept Lett. 2017 Nov 17;24(9):809-816. doi: 10.2174/0929866524666170728151401.
8
Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats.戈德布拉特高血压大鼠未夹闭肾脏近端肾小管血管紧张素II水平及对AT1受体阻断的肾功能反应
Hypertension. 1999 Jan;33(1):102-7. doi: 10.1161/01.hyp.33.1.102.
9
New insights into actions of the renin-angiotensin system in the kidney: concentrating on the Ang II receptors and the newly described Ang-(1-7) and its receptor.肾素 - 血管紧张素系统在肾脏中作用的新见解：聚焦于血管紧张素II受体以及新描述的血管紧张素 -（1 - 7）及其受体。
Semin Nephrol. 2001 Nov;21(6):535-43. doi: 10.1053/snep.2001.26792.
10
The CNS renin-angiotensin system.中枢神经系统肾素-血管紧张素系统。
Cell Tissue Res. 2006 Nov;326(2):599-616. doi: 10.1007/s00441-006-0190-8. Epub 2006 Mar 23.
引用本文的文献
1
Targeting the Renin-Angiotensin-Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins.针对肾素-血管紧张素-醛固酮系统预防发育起源性高血压和肾脏疾病。
Int J Mol Sci. 2021 Feb 25;22(5):2298. doi: 10.3390/ijms22052298.
2
Influence of high glucose on mesangial cell-derived exosome composition, secretion and cell communication.高糖对系膜细胞来源的外泌体组成、分泌和细胞通讯的影响。
Sci Rep. 2019 Apr 18;9(1):6270. doi: 10.1038/s41598-019-42746-1.
3
Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.胎儿编程与血管紧张素-(1-7)轴：实验与临床数据的综述。
Clin Sci (Lond). 2019 Jan 8;133(1):55-74. doi: 10.1042/CS20171550. Print 2019 Jan 15.
4
Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.肥胖与青少年期早产儿的高血压和血管紧张素 II 水平升高有关，但血管紧张素-(1-7)水平降低。
J Pediatr. 2019 Feb;205:55-60.e1. doi: 10.1016/j.jpeds.2018.09.058. Epub 2018 Nov 5.
5
Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity.青春期早产与肾素-血管紧张素系统的关系：性别和肥胖的影响。
J Hypertens. 2018 Oct;36(10):2092-2101. doi: 10.1097/HJH.0000000000001801.
6
Intracrine action of angiotensin II in mesangial cells: subcellular distribution of angiotensin II receptor subtypes AT and AT.血管紧张素 II 在系膜细胞中的自分泌作用：血管紧张素 II 受体亚型 AT 和 AT 的亚细胞分布。
Mol Cell Biochem. 2018 Nov;448(1-2):265-274. doi: 10.1007/s11010-018-3331-y. Epub 2018 Feb 17.
7
Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways.血管紧张素 -（1 - 7）与抗纤维化信号通路的调控
J Cell Signal (Los Angel). 2017 Mar;2(1). doi: 10.4172/2576-1471.1000134. Epub 2017 Jan 27.
8
Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells.鉴定二肽基肽酶3为人类HK-2肾上皮细胞中血管紧张素-(1-7)降解肽酶。
Peptides. 2016 Sep;83:29-37. doi: 10.1016/j.peptides.2016.06.005. Epub 2016 Jun 15.
9
Calcitriol regulates angiotensin-converting enzyme and angiotensin converting-enzyme 2 in diabetic kidney disease.骨化三醇调节糖尿病肾病中的血管紧张素转换酶和血管紧张素转换酶2。
Mol Biol Rep. 2016 May;43(5):397-406. doi: 10.1007/s11033-016-3971-5. Epub 2016 Mar 12.
10
Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?肾素-血管紧张素系统的生化评估：益处、弊端与绝对因素？
Am J Physiol Heart Circ Physiol. 2016 Jan 15;310(2):H137-52. doi: 10.1152/ajpheart.00618.2015. Epub 2015 Oct 16.
本文引用的文献
1
Nuclear expression of renin-angiotensin system components in NRK-52E renal epithelial cells.肾素-血管紧张素系统成分在NRK-52E肾上皮细胞中的核表达。
J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1135-48. doi: 10.1177/1470320313515039. Epub 2014 Jun 24.
2
Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep.绵羊脑髓和脑脊液中表达的血管紧张素-(1-7)神经肽酶的证据。
J Neurochem. 2014 Jul;130(2):313-23. doi: 10.1111/jnc.12720. Epub 2014 Apr 19.
3
Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways.血管紧张素转换酶2-血管紧张素（1-7）-MAS受体轴的最新进展：胎儿编程、性别差异及细胞内信号通路
Front Endocrinol (Lausanne). 2014 Jan 9;4:201. doi: 10.3389/fendo.2013.00201.
4
Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase.大鼠海马中血管紧张素 II 非依赖性血管紧张素-(1-7)的形成：涉及金属肽酶。
Hypertension. 2013 Nov;62(5):879-85. doi: 10.1161/HYPERTENSIONAHA.113.01613. Epub 2013 Sep 16.
5
Nonclassical renin-angiotensin system and renal function.非经典肾素-血管紧张素系统与肾功能。
Compr Physiol. 2012 Oct;2(4):2733-52. doi: 10.1002/cphy.c120002.
6
Network modeling reveals steps in angiotensin peptide processing.网络建模揭示了血管紧张素肽加工的步骤。
Hypertension. 2013 Mar;61(3):690-700. doi: 10.1161/HYPERTENSIONAHA.111.00318. Epub 2013 Jan 2.
7
Novel roles of nuclear angiotensin receptors and signaling mechanisms.核血管紧张素受体的新作用及其信号转导机制。
Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R518-30. doi: 10.1152/ajpregu.00525.2011. Epub 2011 Dec 14.
8
Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model.来自体外研究和相关的细胞内血管紧张素 II 转基因小鼠模型的启示。
Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R482-93. doi: 10.1152/ajpregu.00493.2011. Epub 2011 Dec 14.
9
Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney.肾脏近端小管中细胞内血管紧张素系统的功能证据。
Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R494-509. doi: 10.1152/ajpregu.00487.2011. Epub 2011 Dec 14.
10
Intracardiac intracellular angiotensin system in diabetes.心脏细胞内肾素-血管紧张素系统与糖尿病
Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R510-7. doi: 10.1152/ajpregu.00512.2011. Epub 2011 Dec 14.
Zotero 插件