前列腺癌亚型PINg生物标志物与预后：清晰度正在显现吗？
Prostate cancer SubtyPINg biomarKers and outcome: is clarity emERGing?
作者信息
Smith Steven C, Tomlins Scott A
机构信息
Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan. Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Department of Pathology, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan. Department of Urology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan. Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.
出版信息
Clin Cancer Res. 2014 Sep 15;20(18):4733-6. doi: 10.1158/1078-0432.CCR-14-0818. Epub 2014 Jun 18.
Abstract
Molecular prostate cancer subtypes have been proposed on the basis of mutually exclusive SPINK1 and ERG overexpression, with conflicting reports on their prognostic ability. Flavin and colleagues report that SPINK1 is neither prognostic nor absolutely mutually exclusive with ERG, raising important questions about prostate cancer molecular subtyping and prognostic biomarker evaluation.
摘要
分子前列腺癌亚型是基于SPINK1和ERG的互斥过表达提出的，但其预后能力的报道相互矛盾。弗莱文及其同事报告称，SPINK1既无预后价值，也并非与ERG绝对互斥，这引发了有关前列腺癌分子分型和预后生物标志物评估的重要问题。
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