Qian Yuanyu, Liu Jie, Ma Jinling, Meng Qingyi, Peng Chaoying
Department of Emergency, Chinese PLA General Hospital, Beijing 100853, P.R. China.
Exp Ther Med. 2014 Jul;8(1):243-247. doi: 10.3892/etm.2014.1678. Epub 2014 Apr 14.
In the present study, the effect of initial body temperature changes on myocardial enzyme levels and cardiac function in acute myocardial infarction (AMI) patients was investigated. A total of 315 AMI patients were enrolled and the mean temperature was calculated based on their body temperature within 24 h of admission to hospital. The patients were divided into four groups according to their normal body temperature: Group A, <36.5°C; group B, ≥36.5°C and <37.0°C; group C, ≥37.0°C and <37.5°C and group D, ≥37.5°C. The levels of percutaneous coronary intervention, myocardial enzymes and troponin T (TNT), as well as cardiac ultrasound images, were analyzed. Statistically significant differences in the quantity of creatine kinase at 12 and 24 h following admission were identified between group A and groups C and D (P<0.01). A significant difference in TNT at 12 h following admission was observed between groups A and D (P<0.05), however, this difference was not observed with groups B and C. The difference in TNT between the groups at 24 h following admission was not statistically significant (P>0.05). Significant differences in lactate dehydrogenase at 12 and 24 h following admission were observed between groups A and D (P<0.05), however, differences were not observed with groups B and C (P>0.05). Significant differences in glutamic-oxaloacetic transaminase at 12 and 24 h following admission were observed between groups A and D (P<0.05), however, differences were not observed in groups B and C (P>0.05). However, no significant differences were identified in cardiac function index between all the groups. Therefore, the results of the present study indicated that AMI patients with low initial body temperatures exhibited decreased levels of myocardial enzymes and TNT. Thus, the observation of an initially low body temperature may be used as a protective factor for AMI and may improve the existing clinical program.
在本研究中，调查了急性心肌梗死（AMI）患者初始体温变化对心肌酶水平和心功能的影响。共纳入315例AMI患者，并根据入院24小时内的体温计算平均体温。根据正常体温将患者分为四组：A组，体温<36.5°C；B组，体温≥36.5°C且<37.0°C；C组，体温≥37.0°C且<37.5°C；D组，体温≥37.5°C。分析了经皮冠状动脉介入治疗情况、心肌酶和肌钙蛋白T（TNT）水平以及心脏超声图像。入院后12小时和24小时时，A组与C组和D组之间肌酸激酶量存在统计学显著差异（P<0.01）。入院后12小时时，A组与D组之间TNT存在显著差异（P<0.05），但B组和C组之间未观察到这种差异。入院后24小时时，各组之间TNT差异无统计学意义（P>0.05）。入院后12小时和24小时时，A组与D组之间乳酸脱氢酶存在显著差异（P<0.05），但B组和C组之间未观察到差异（P>0.05）。入院后12小时和24小时时，A组与D组之间谷草转氨酶存在显著差异（P<0.05），但B组和C组之间未观察到差异（P>0.05）。然而，所有组的心功能指标均未发现显著差异。因此，本研究结果表明，初始体温较低的AMI患者心肌酶和TNT水平降低。因此，观察到初始体温较低可能作为AMI的一个保护因素，并可能改善现有的临床方案。
