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桑寄生苷对人胚肺成纤维细胞和肺癌A549细胞凋亡影响的差异。

Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells.

作者信息

Chen Jian-Ping, Xu DE-Guo, Yu Xiao-Yi, Zhao Feng-Ming, Xu Dong-Qing, Zhang Xu, Cai Bao-Chang, Wang Ming-Yan

机构信息

Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China.

出版信息

Oncol Lett. 2014 Apr;7(4):927-932. doi: 10.3892/ol.2014.1850. Epub 2014 Feb 3.

DOI:10.3892/ol.2014.1850
PMID:24944645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3961276/
Abstract

Morroniside is a water-soluble compound extracted from the fruit of and is used to protect lung activity against aging. In the present study, the manner in which morroniside regulates normal lung and cancer cells was examined. The human embryonic lung fibroblast (HELF) cell line and lung cancer A549 cell line, and their responses to morroniside treatment, were examined. Results showed that morroniside reverses the apoptotic effect of HO on HELF cell growth, protecting cell proliferation and normal cell morphology and inhibiting apoptosis. However, these effects were not present in A549 cells. Western blotting showed that morroniside also markedly downregulated retinoblastoma protein in HELF cells. These results suggest that morroniside treatment exhibits different effects on apoptosis in HELF and A549 cells, making it a viable compound for decreasing the side effects of anticancer medicines in normal cells.

摘要

莫诺苷是从[具体植物名称]果实中提取的一种水溶性化合物，用于保护肺部活动以抵抗衰老。在本研究中，检测了莫诺苷调节正常肺细胞和癌细胞的方式。检测了人胚肺成纤维细胞（HELF）系和肺癌A549细胞系，以及它们对莫诺苷处理的反应。结果表明，莫诺苷可逆转HO对HELF细胞生长的凋亡作用，保护细胞增殖和正常细胞形态并抑制凋亡。然而，这些作用在A549细胞中不存在。蛋白质免疫印迹法显示，莫诺苷还显著下调了HELF细胞中的视网膜母细胞瘤蛋白。这些结果表明，莫诺苷处理对HELF和A549细胞的凋亡表现出不同的作用，使其成为一种可行的化合物，可用于降低抗癌药物对正常细胞的副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/d2f387037f1f/OL-07-04-0927-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/dcfdef9c7f5c/OL-07-04-0927-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/057fcf04a058/OL-07-04-0927-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/b7c32ed74c66/OL-07-04-0927-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/d2f387037f1f/OL-07-04-0927-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/dcfdef9c7f5c/OL-07-04-0927-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/057fcf04a058/OL-07-04-0927-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/b7c32ed74c66/OL-07-04-0927-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b79/3961276/d2f387037f1f/OL-07-04-0927-g03.jpg

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