Onoyama Masaki, Azuma Kazuo, Tsuka Takeshi, Imagawa Tomohiro, Osaki Tomohiro, Minami Saburo, Ogawa Nobuhiko, Okamoto Yoshiharu
The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Yamaguchi 753-8515, Japan.
Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553, Japan.
Oncol Lett. 2014 Apr;7(4):1147-1150. doi: 10.3892/ol.2014.1865. Epub 2014 Feb 10.
The present study used indocyanine green (ICG) and a broadband light source apparatus [photodynamic hyperthermal therapy (PHT) group] in order to treat a colon 26 tumor-bearing mouse model. The other groups were administered either ICG alone (ICG group), light alone (light group) or no treatment (control group). Following the treatment, tumor growth was measured. Nine days after the treatment, the tumors were resected and histological and immunohistological examinations were performed. In the PHT group, the growth rates of the tumor tissues were significantly decreased compared with those observed in the other groups (P<0.05). The proportion of necrotic areas in the PHT and light groups were increased significantly compared with those observed in the ICG and control groups. However, there were no significant differences between the PHT and light groups. The proportion of Ki-67 in the PHT and light groups was less than that observed in the ICG and control groups. The number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling-positive cells in the PHT group was significantly increased compared with that observed in the other groups. These data indicate that PHT is effective and .
本研究使用吲哚菁绿（ICG）和宽带光源设备（光动力热疗（PHT）组）来治疗结肠癌荷瘤小鼠模型。其他组分别单独给予ICG（ICG组）、单独给予光照（光照组）或不进行治疗（对照组）。治疗后，测量肿瘤生长情况。治疗九天后，切除肿瘤并进行组织学和免疫组织学检查。在PHT组中，肿瘤组织的生长速率与其他组相比显著降低（P<0.05）。与ICG组和对照组相比，PHT组和光照组中坏死区域的比例显著增加。然而，PHT组和光照组之间没有显著差异。PHT组和光照组中Ki-67的比例低于ICG组和对照组。与其他组相比，PHT组中末端脱氧核苷酸转移酶介导dUTP缺口末端标记阳性细胞的数量显著增加。这些数据表明PHT是有效的且…… （原文此处不完整）
