细胞黏附蛋白的改变与心肌病
Alterations in cell adhesion proteins and cardiomyopathy.
作者信息
Li Jifen
机构信息
Jifen Li, Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
出版信息
World J Cardiol. 2014 May 26;6(5):304-13. doi: 10.4330/wjc.v6.i5.304.
Abstract
Cell adhesive junction is specialized intercellular structure composed of cell adhesion proteins. They are essential to connect adjacent heart muscle cell and make heart contraction effectively and properly. Clinical and genetic studies have revealed close relationship between cell adhesive proteins and the occurrence of various cardiomyopathies. Here we will review recent development on the disease phenotype, potential cellular and molecular mechanism related to cell adhesion molecules, with particular disease pathogenesis learned from genetic manipulated murine models.
摘要
细胞黏附连接是由细胞黏附蛋白组成的特殊细胞间结构。它们对于连接相邻的心肌细胞并使心脏有效且正常地收缩至关重要。临床和遗传学研究已揭示细胞黏附蛋白与各种心肌病的发生之间存在密切关系。在此，我们将综述与细胞黏附分子相关的疾病表型、潜在细胞和分子机制的最新进展，特别是从基因操作小鼠模型中了解到的疾病发病机制。
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