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揭示由HIV抗逆转录病毒疗法诱发的妊娠期隐球菌性脑膜炎免疫重建炎症综合征及产后矛盾性加重。

Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation.

作者信息

Kiggundu Reuben, Rhein Joshua, Meya David B, Boulware David R, Bahr Nathan C

机构信息

Infectious Disease Institute, Makerere University, Kampala, Uganda.

Infectious Disease Institute, Makerere University, Kampala, Uganda ; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Center for Infectious Diseases & Microbiology Translational Research, University of Minnesota, Minneapolis, MN, USA.

出版信息

Med Mycol Case Rep. 2014 May 29;5:16-9. doi: 10.1016/j.mmcr.2014.05.001. eCollection 2014 Jul.

DOI:10.1016/j.mmcr.2014.05.001
PMID:24944885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4060260/
Abstract

Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS) is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS) and markedly worsened postpartum after delivery (paradoxical IRIS).

摘要

由于艾滋病病毒负担沉重，隐球菌病是非洲脑膜炎最常见的病因。免疫重建炎症综合征（IRIS）是隐球菌性脑膜炎常见且致命的并发症。我们报告一例孕妇隐球菌性IRIS致死病例，该病例在开始抗逆转录病毒治疗后发病（暴露型IRIS），产后病情显著恶化（矛盾型IRIS）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a08f/4060260/52ea6b506e97/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a08f/4060260/52ea6b506e97/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a08f/4060260/52ea6b506e97/gr1.jpg

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