Freitas Amanda Osório Ayres, Marquezan Mariana, Nojima Matilde da Cunha Gonçalves, Alviano Daniela Sales, Maia Lucianne Cople
Dental Press J Orthod. 2014 Mar-Apr;19(2):46-55. doi: 10.1590/2176-9451.19.2.046-055.oar.
To investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota.
The search for articles was conducted in PubMed; ISI Web of Knowledge and Ovid databases, including articles published in English until May 17th, 2012. They should report human observational studies presenting the following keywords: "fixed orthodontic appliance" AND "microbiological colonization"; OR "periodontal pathogens"; OR "Streptococcus"; OR "Lactobacillus"; OR "Candida"; OR "Tannerella forsythia"; OR "Treponema denticola"; OR "Fusobacterium nucleatum"; OR "Actimomyces actinomycetemcomitans"; OR "Prevotella intermedia"; OR "Prevotella nigrescens"; OR "Porphyromonas gingivalis". Articles were previously selected by title and abstract. Articles that met the inclusion criteria were analyzed and classified as having low, moderate or high methodology quality. A new detailed checklist for quality assessment was developed based on the information required for applicable data extraction for reviews. The study design, sample, follow-up period, collection and microbial analysis methods, statistical treatment, results and discussion were assessed.
The initial search retrieved 305 articles of which 33 articles were selected by title and abstract. After full-text reading, 8 articles met the inclusion criteria, out of which 4 articles were classified as having low and 4 as moderate methodological quality. The moderate methodological quality studies were included in the systematic review.
The literature revealed moderate evidence that the presence of fixed appliances influences the quantity and quality of oral microbiota.
探讨是否有科学证据支持正畸固定矫治器的存在会影响口腔微生物群这一假说。
在PubMed、ISI Web of Knowledge和Ovid数据库中检索文章，包括截至2012年5月17日发表的英文文章。文章应报告人类观察性研究，并包含以下关键词：“固定正畸矫治器”以及“微生物定植”；或“牙周病原体”；或“链球菌”；或“乳酸杆菌”；或“念珠菌”；或“福赛坦纳菌”；或“具核梭杆菌”；或“伴放线放线杆菌”；或“中间普氏菌”；或“变黑普氏菌”；或“牙龈卟啉单胞菌”。文章首先通过标题和摘要进行筛选。符合纳入标准的文章进行分析，并根据方法学质量分为低、中、高三个等级。基于综述适用数据提取所需信息，制定了一份新的详细质量评估清单。对研究设计、样本、随访期、收集和微生物分析方法、统计学处理、结果及讨论进行评估。
初步检索得到305篇文章，其中33篇通过标题和摘要筛选出来。全文阅读后，8篇文章符合纳入标准，其中4篇文章方法学质量为低，4篇为中等。中等方法学质量的研究纳入系统评价。
文献显示有中等证据表明固定矫治器的存在会影响口腔微生物群的数量和质量。
