Rissi Daniel R, Barber Renee, Burnum Annabelle, Miller Andrew D
Department of Pathology and Athens Veterinary Diagnostic Laboratory (Rissi, Burnum) and Neurology and Neurosurgery Service, University of Georgia College of Veterinary Medicine, Athens, GA (Barber).
Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY (Miller).
J Vet Diagn Invest. 2017 Jan;29(1):126-132. doi: 10.1177/1040638716673127. Epub 2016 Dec 20.
Spinal cord glioma is uncommonly reported in dogs. We describe the clinicopathologic and diagnostic features of 7 cases of canine spinal cord glioma and briefly review the veterinary literature on this topic. The median age at presentation was 7.2 y. Six females and 1 male were affected and 4 dogs were brachycephalic. The clinical course lasted from 3 d to 12 wk, and clinical signs were progressive and associated with multiple suspected neuroanatomic locations in the spinal cord. Magnetic resonance imaging of 6 cases revealed T2-weighted hyperintense lesions with variable contrast enhancement in the spinal cord. All dogs had a presumptive clinical diagnosis of intraparenchymal neoplasia or myelitis based on history, advanced imaging, and cerebrospinal fluid analysis. Euthanasia was elected in all cases because of poor outcome despite anti-inflammatory or immunosuppressive treatment or because of poor prognosis at the time of diagnosis. Tumor location during autopsy ranged from C1 to L6, with no clear predilection for a specific spinal cord segment. The diagnosis was based on histopathology and the immunohistochemistry expression of glial fibrillary acidic protein, oligodendrocyte lineage transcription factor 2, 2',3'-cyclic-nucleotide 3'-phosphodiesterase, neuron-specific enolase, synaptophysin, and Ki-67. Diagnoses consisted of 4 cases of oligodendroglioma, 2 cases of gliomatosis cerebri, and 1 astrocytoma. This case series further defines the clinicopathologic features of canine spinal glioma and highlights the need for comprehensive immunohistochemistry in addition to routine histopathology to confirm the diagnosis of these tumors.
脊髓胶质瘤在犬类中鲜有报道。我们描述了7例犬脊髓胶质瘤的临床病理和诊断特征，并简要回顾了关于该主题的兽医文献。发病时的中位年龄为7.2岁。6只雌性和1只雄性犬患病，4只为短头品种。临床病程持续3天至12周，临床症状呈进行性，与脊髓中多个疑似神经解剖位置相关。6例犬的磁共振成像显示脊髓内T2加权高信号病变，增强扫描表现各异。所有犬根据病史、高级影像学检查和脑脊液分析，临床初步诊断为实质内肿瘤或脊髓炎。尽管进行了抗炎或免疫抑制治疗，但由于预后不良或诊断时预后不佳，所有病例均选择实施安乐死。尸检时肿瘤位置从C1至L6，对特定脊髓节段无明显偏好。诊断基于组织病理学以及胶质纤维酸性蛋白、少突胶质细胞系转录因子2、2',3'-环核苷酸3'-磷酸二酯酶、神经元特异性烯醇化酶、突触素和Ki-67的免疫组化表达。诊断结果包括4例少突胶质细胞瘤、2例大脑胶质瘤病和1例星形细胞瘤。该病例系列进一步明确了犬脊髓胶质瘤的临床病理特征，并强调除常规组织病理学外，还需要综合免疫组化来确诊这些肿瘤。
