Sabri Merav, Humphries Colin, Verber Matthew, Liebenthal Einat, Binder Jeffrey R, Mangalathu Jain, Desai Anjali
Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Neuropsychologia. 2014 Aug;61:269-79. doi: 10.1016/j.neuropsychologia.2014.06.009. Epub 2014 Jun 16.
Whether and how working memory disrupts or alters auditory selective attention is unclear. We compared simultaneous event-related potentials (ERP) and functional magnetic resonance imaging (fMRI) responses associated with task-irrelevant sounds across high and low working memory load in a dichotic-listening paradigm. Participants performed n-back tasks (1-back, 2-back) in one ear (Attend ear) while ignoring task-irrelevant speech sounds in the other ear (Ignore ear). The effects of working memory load on selective attention were observed at 130-210ms, with higher load resulting in greater irrelevant syllable-related activation in localizer-defined regions in auditory cortex. The interaction between memory load and presence of irrelevant information revealed stronger activations primarily in frontal and parietal areas due to presence of irrelevant information in the higher memory load. Joint independent component analysis of ERP and fMRI data revealed that the ERP component in the N1 time-range is associated with activity in superior temporal gyrus and medial prefrontal cortex. These results demonstrate a dynamic relationship between working memory load and auditory selective attention, in agreement with the load model of attention and the idea of common neural resources for memory and attention.
工作记忆是否以及如何干扰或改变听觉选择性注意尚不清楚。我们在双耳分听范式中，比较了高工作记忆负荷和低工作记忆负荷下与任务无关声音相关的同步事件相关电位（ERP）和功能磁共振成像（fMRI）反应。参与者在一只耳朵（ attended ear）执行n-back任务（1-back、2-back），同时忽略另一只耳朵（Ignore ear）中与任务无关的语音。在130 - 210毫秒时观察到工作记忆负荷对选择性注意的影响，较高负荷导致听觉皮层中定位器定义区域内与无关音节相关的激活更强。记忆负荷与无关信息的存在之间的相互作用表明，由于在较高记忆负荷下存在无关信息，主要在额叶和顶叶区域有更强的激活。ERP和fMRI数据的联合独立成分分析表明，N1时间范围内的ERP成分与颞上回和内侧前额叶皮层的活动相关。这些结果证明了工作记忆负荷与听觉选择性注意之间的动态关系，这与注意的负荷模型以及记忆和注意的共同神经资源的观点一致。
