胆红素在大鼠开放性切除伤口模型中的促愈合作用。
Pro-healing effects of bilirubin in open excision wound model in rats.
作者信息
Ahanger Azad A, Leo Marie D, Gopal Anu, Kant Vinay, Tandan Surendra K, Kumar Dinesh
机构信息
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Bareilly, India.
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Int Wound J. 2016 Jun;13(3):398-402. doi: 10.1111/iwj.12319. Epub 2014 Jun 20.
Bilirubin, a by-product of heme degradation, has an important role in cellular protection. Therefore, we speculated that bilirubin could be of potential therapeutic value in wound healing. To validate the hypothesis, we used a full-thickness cutaneous wound model in rats. Bilirubin (30 mg/kg) was administered intraperitoneally every day for 9 days. The surface area of the wound was measured on days 0, 2, 4, 7 and 10 after the creation of the wound. The granulation tissue was collected on day 10 post-wounding for analysing various parameters of wound healing. Bilirubin treatment accelerated wound contraction and increased hydroxyproline and glucosamine contents. mRNA expression of pro-inflammatory factors such as intercellular cell adhesion molecule-1 (ICAM-1) and tumour necrosis factor-α (TNF-α) were down-regulated and that of anti-inflammatory cytokine interleukin-10 (IL-10) was up-regulated. The findings suggest that bilirubin could be a new agent for enhancing cutaneous wound healing.
胆红素作为血红素降解的副产物，在细胞保护中发挥着重要作用。因此，我们推测胆红素在伤口愈合中可能具有潜在的治疗价值。为验证这一假设，我们使用了大鼠全层皮肤伤口模型。每天腹腔注射胆红素（30 mg/kg），持续9天。在伤口形成后的第0、2、4、7和10天测量伤口表面积。在伤口形成后第10天收集肉芽组织，以分析伤口愈合的各种参数。胆红素治疗加速了伤口收缩，增加了羟脯氨酸和氨基葡萄糖含量。促炎因子如细胞间黏附分子-1（ICAM-1）和肿瘤坏死因子-α（TNF-α）的mRNA表达下调，抗炎细胞因子白细胞介素-10（IL-10）的mRNA表达上调。这些发现表明，胆红素可能是一种促进皮肤伤口愈合的新型药物。
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