Iglói Kinga, Doeller Christian F, Paradis Anne-Lise, Benchenane Karim, Berthoz Alain, Burgess Neil, Rondi-Reig Laure
Collège de France, LPPA, Paris 75005, France Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, Sorbonne Universités, UPMC Univ Paris 06, UMR-S 8246/ UM CR18, Paris F-75005, France Neuroscience Paris Seine, INSERM, UMR-S 1130, Cerebellum, Navigation and Memory Team, Paris F-75005, France Neuroscience Paris Seine, CNRS, UMR 8246, Cerebellum, Navigation and Memory Team, Paris F-75005, France Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience, University of Geneva, Geneva, Switzerland Current address: Fundamental Neuroscience Department, Geneva 1211, Switzerland.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
Cereb Cortex. 2015 Nov;25(11):4146-54. doi: 10.1093/cercor/bhu132. Epub 2014 Jun 19.
To examine the cerebellar contribution to human spatial navigation we used functional magnetic resonance imaging and virtual reality. Our findings show that the sensory-motor requirements of navigation induce activity in cerebellar lobules and cortical areas known to be involved in the motor loop and vestibular processing. By contrast, cognitive aspects of navigation mainly induce activity in a different cerebellar lobule (VIIA Crus I). Our results demonstrate a functional link between cerebellum and hippocampus in humans and identify specific functional circuits linking lobule VIIA Crus I of the cerebellum to medial parietal, medial prefrontal, and hippocampal cortices in nonmotor aspects of navigation. They further suggest that Crus I belongs to 2 nonmotor loops, involved in different strategies: place-based navigation is supported by coherent activity between left cerebellar lobule VIIA Crus I and medial parietal cortex along with right hippocampus activity, while sequence-based navigation is supported by coherent activity between right lobule VIIA Crus I, medial prefrontal cortex, and left hippocampus. These results highlight the prominent role of the human cerebellum in both motor and cognitive aspects of navigation, and specify the cortico-cerebellar circuits by which it acts depending on the requirements of the task.
为了研究小脑对人类空间导航的作用，我们使用了功能磁共振成像和虚拟现实技术。我们的研究结果表明，导航的感觉运动需求会诱发小脑小叶和已知参与运动环路及前庭处理的皮质区域的活动。相比之下，导航的认知方面主要诱发不同小脑小叶（VIIA Crus I）的活动。我们的结果证明了人类小脑与海马体之间的功能联系，并确定了在导航的非运动方面将小脑的VIIA Crus I小叶与内侧顶叶、内侧前额叶和海马皮质连接起来的特定功能回路。它们进一步表明，Crus I属于两个非运动环路，参与不同的策略：基于地点的导航由左小脑小叶VIIA Crus I与内侧顶叶皮质以及右海马体活动之间的连贯活动支持，而基于序列的导航由右小叶VIIA Crus I、内侧前额叶皮质和左海马体之间的连贯活动支持。这些结果突出了人类小脑在导航的运动和认知方面的重要作用，并根据任务需求明确了其发挥作用的皮质 - 小脑回路。
