表达传染性法氏囊病VP2蛋白的金丝雀痘病毒作为鸡的免疫原
Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens.
作者信息
Zanetti Flavia Adriana, Grand María Daniela Conte, Mitarotonda Romina Cristina, Taboga Oscar Alberto, Calamante Gabriela
机构信息
Consejo Nacional de Investigaciones Científicas y Tecnológicas Ciudad Autónoma de Buenos Aires Argentina.
Instituto de Biotecnología Centro de Investigaciones en Ciencias Veterinarias y Agronómicas Instituto Nacional de Tecnología Agropecuaria Castelar, Buenos Aires Argentina.
出版信息
Braz J Microbiol. 2014 May 19;45(1):231-4. doi: 10.1590/s1517-83822014000100032. eCollection 2014.
Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing antibodies when inoculated in specific pathogen-free chickens demonstrating that CNPV platform is usefulness to develop immunogens for chickens.
获得了携带传染性法氏囊病病毒（IBDV）VP2蛋白编码序列的金丝雀痘病毒（CNPV）。这些病毒能够在体外表达VP2蛋白，并在接种到无特定病原体的鸡中时诱导产生IBDV中和抗体，这表明CNPV平台对于开发鸡用免疫原是有用的。
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