Alkie Tamiru Negash, Rautenschlein Silke
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada.
Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, Germany,
Vet Med (Auckl). 2016 Jan 19;7:9-18. doi: 10.2147/VMRR.S68905. eCollection 2016.
Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.
传染性法氏囊病病毒（IBDV）感染法氏囊内未成熟的B淋巴细胞，并可能导致严重的免疫抑制。它仍然是家禽业经济损失的主要原因。IBDV具有分段双链RNA基因组，易于发生基因变异。因此，存在具有不同基因型和表型多样性的IBDV分离株。了解该病毒的这些特征及其引发的保护性免疫机制对于开发疗效更佳的疫苗至关重要。在本综述中，我们重点介绍了病毒进化模式以及预防策略的新进展，主要是新一代疫苗的研发，这在未来仍将是研究以及实际应用中备受关注的领域。
