家禽传染性法氏囊病病毒：现状与未来展望
Infectious bursal disease virus in poultry: current status and future prospects.
作者信息
Alkie Tamiru Negash, Rautenschlein Silke
机构信息
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Canada.
Clinic for Poultry, University of Veterinary Medicine Hannover, Hannover, Germany,
出版信息
Vet Med (Auckl). 2016 Jan 19;7:9-18. doi: 10.2147/VMRR.S68905. eCollection 2016.
Abstract
Infectious bursal disease virus (IBDV) affects immature B lymphocytes of the bursa of Fabricius and may cause significant immunosuppression. It continues to be a leading cause of economic losses in the poultry industry. IBDV, having a segmented double-stranded RNA genome, is prone to genetic variation. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist. Understanding these features of the virus and the mechanisms of protective immunity elicited thereof is necessary for developing vaccines with improved efficacy. In this review, we highlighted the pattern of virus evolution and new developments in prophylactic strategies, mainly the development of new generation vaccines, which will continue to be of interest for research as well as field application in the future.
摘要
传染性法氏囊病病毒（IBDV）感染法氏囊内未成熟的B淋巴细胞，并可能导致严重的免疫抑制。它仍然是家禽业经济损失的主要原因。IBDV具有分段双链RNA基因组，易于发生基因变异。因此，存在具有不同基因型和表型多样性的IBDV分离株。了解该病毒的这些特征及其引发的保护性免疫机制对于开发疗效更佳的疫苗至关重要。在本综述中，我们重点介绍了病毒进化模式以及预防策略的新进展，主要是新一代疫苗的研发，这在未来仍将是研究以及实际应用中备受关注的领域。
相似文献
1
Infectious bursal disease virus in poultry: current status and future prospects.家禽传染性法氏囊病病毒：现状与未来展望
Vet Med (Auckl). 2016 Jan 19;7:9-18. doi: 10.2147/VMRR.S68905. eCollection 2016.
2
Infectious bursal disease virus in chickens: prevalence, impact, and management strategies.鸡的传染性法氏囊病病毒：流行情况、影响及管理策略
Vet Med (Auckl). 2019 Aug 5;10:85-97. doi: 10.2147/VMRR.S185159. eCollection 2019.
3
Protective efficacy of intermediate and intermediate plus infectious bursal disease virus (IBDV) vaccines against very virulent IBDV in commercial broilers.中等毒力和中等毒力加传染性法氏囊病病毒（IBDV）疫苗对商品肉鸡中强毒力IBDV的保护效力。
Avian Dis. 2005 Jun;49(2):231-7. doi: 10.1637/7310-112204R.
4
Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha.传染性法氏囊病病毒感染细胞在干扰素α作用下细胞凋亡加剧。
J Virol. 2018 May 14;92(11). doi: 10.1128/JVI.00364-18. Print 2018 Jun 1.
5
Novel variants of infectious bursal disease virus can severely damage the bursa of fabricius of immunized chickens.新型传染性法氏囊病病毒可严重损害免疫鸡的法氏囊。
Vet Microbiol. 2020 Jan;240:108507. doi: 10.1016/j.vetmic.2019.108507. Epub 2019 Nov 16.
6
Rapid Generation of Attenuated Infectious Bursal Disease Virus from Dual-Promoter Plasmids by Reduction of Viral Ribonucleoprotein Activity.通过降低病毒核糖核蛋白活性从双启动子质粒快速产生减毒传染性法氏囊病病毒
J Virol. 2020 Mar 17;94(7). doi: 10.1128/JVI.01569-19.
7
Modified live infectious bursal disease virus (IBDV) vaccine delays infection of neonatal broiler chickens with variant IBDV compared to turkey herpesvirus (HVT)-IBDV vectored vaccine.与火鸡疱疹病毒（HVT）-传染性法氏囊病病毒（IBDV）载体疫苗相比，改良活传染性法氏囊病病毒疫苗可延迟新生肉鸡感染变异传染性法氏囊病病毒。
Vaccine. 2017 Feb 7;35(6):882-888. doi: 10.1016/j.vaccine.2017.01.005. Epub 2017 Jan 12.
8
Infectious bursal disease virus in Algeria: Detection of highly pathogenic reassortant viruses.阿尔及利亚传染性法氏囊病病毒：高致病性重组病毒的检测。
Infect Genet Evol. 2018 Jun;60:48-57. doi: 10.1016/j.meegid.2018.01.029. Epub 2018 Feb 1.
9
The working mechanism of an immune complex vaccine that protects chickens against infectious bursal disease.一种保护鸡免受传染性法氏囊病侵害的免疫复合物疫苗的作用机制。
Immunology. 1998 Nov;95(3):494-500. doi: 10.1046/j.1365-2567.1998.00617.x.
10
Efficacy of Recombinant HVT-IBD Vaccines Administered to Broiler Chicks from a Single Breeder Flock at 30 and 60 Weeks of Age.对来自同一育种鸡群、30周龄和60周龄的肉仔鸡接种重组HVT-IBD疫苗的效果。
Avian Dis. 2016 Sep;60(3):603-12. doi: 10.1637/11344-120815-Reg.1.
引用本文的文献
1
Genetic and Environmental Factors Contributing to the Pathogenesis of Vertebral Osteomyelitis Caused by in Broiler Chicken.导致肉鸡椎骨骨髓炎发病机制的遗传和环境因素。 （注：原文中“in Broiler Chicken”前似乎缺失了某种病原体相关内容，这里按字面翻译）
Animals (Basel). 2025 Aug 8;15(16):2327. doi: 10.3390/ani15162327.
2
Pathology and VP2-Based Characterization of Infectious Bursal Disease Virus Associated with an Outbreak in Layer Chickens in Ghana.加纳蛋鸡群中一起传染性法氏囊病病毒暴发的病理学及基于VP2的特征分析
Pathogens. 2024 Dec 17;13(12):1115. doi: 10.3390/pathogens13121115.
3
Infectious Bursal Disease Virus in Algeria: Persistent Circulation of Very Virulent Strains in Spite of Control Efforts.阿尔及利亚的传染性法氏囊病病毒：尽管采取了防控措施，超强毒株仍持续传播。
Animals (Basel). 2024 Dec 8;14(23):3543. doi: 10.3390/ani14233543.
4
Comparison of Three Different IBD Vaccination Protocols in Broiler Chicken-Efficacy, Serological Baselines and Histo-Pathological Lesions in the Bursa of Fabricius.三种不同鸡传染性法氏囊病疫苗接种方案在肉鸡中的比较——效力、血清学基线及法氏囊组织病理学病变
Animals (Basel). 2024 Oct 29;14(21):3116. doi: 10.3390/ani14213116.
5
Clarification of a unique mucosal vaccination route for improved systemic and mucosal immune response in broiler.明确一种独特的黏膜疫苗接种途径以改善肉鸡的全身和黏膜免疫反应。
Heliyon. 2024 Oct 19;10(20):e39621. doi: 10.1016/j.heliyon.2024.e39621. eCollection 2024 Oct 30.
6
Rapid identification, pathotyping and quantification of infectious bursal disease virus by high-resolution melting curve quantitative reverse transcription PCR analysis: An innovative technology well-suited for real-time large-scale epidemiological surveillance.通过高分辨率熔解曲线定量逆转录PCR分析对传染性法氏囊病病毒进行快速鉴定、分型和定量：一项适用于实时大规模流行病学监测的创新技术。
Poult Sci. 2024 Dec;103(12):104440. doi: 10.1016/j.psj.2024.104440. Epub 2024 Oct 21.
7
Recent Advances in Oral Vaccines for Animals.动物口服疫苗的最新进展
Vet Sci. 2024 Aug 5;11(8):353. doi: 10.3390/vetsci11080353.
8
Genotype classification and pathogenicity of infectious bursal disease virus circulating in vaccinated broiler chicken farms.流行于免疫鸡场的传染性法氏囊病病毒的基因型分类和致病性。
Vet Res Commun. 2024 Oct;48(5):3089-3104. doi: 10.1007/s11259-024-10468-z. Epub 2024 Jul 30.
9
Exploring Variability: Inflammation Mediator Levels across Tissues and Time in Poultry Experimentally Infected by the G1a and G6 Genogroups of Infectious Bursal Disease Virus (IBDV).探索变异性：在实验性感染传染性法氏囊病病毒（IBDV）G1a和G6基因型的家禽中，不同组织和时间的炎症介质水平
Animals (Basel). 2024 May 29;14(11):1619. doi: 10.3390/ani14111619.
10
Modulation of cyclophosphamide-induced immunosuppression and intestinal flora in broiler by deep eutectic solvent extracted polysaccharides of .深共熔溶剂提取的[具体名称未给出]多糖对环磷酰胺诱导的肉鸡免疫抑制和肠道菌群的调节作用
Front Vet Sci. 2024 May 27;11:1415716. doi: 10.3389/fvets.2024.1415716. eCollection 2024.
本文引用的文献
1
Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.从宿主内感染动态跨越到宿主间传播适应性：当前假设与知识的探讨
Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675). doi: 10.1098/rstb.2014.0302.
2
The path forward.前进的道路。
Vaccine. 2015 Jun 8;33 Suppl 2:B60-3. doi: 10.1016/j.vaccine.2015.01.087.
3
gga-miR-9* inhibits IFN production in antiviral innate immunity by targeting interferon regulatory factor 2 to promote IBDV replication.gga - miR - 9* 通过靶向干扰素调节因子2来促进传染性法氏囊病病毒复制，从而抑制抗病毒天然免疫中的干扰素产生。
Vet Microbiol. 2015 Jul 9;178(1-2):41-9. doi: 10.1016/j.vetmic.2015.04.023. Epub 2015 May 1.
4
Evaluation of a Phylogenetic Marker Based on Genomic Segment B of Infectious Bursal Disease Virus: Facilitating a Feasible Incorporation of this Segment to the Molecular Epidemiology Studies for this Viral Agent.基于传染性法氏囊病病毒基因组B片段的系统发育标记物评估：促进将该片段切实纳入该病毒病原体的分子流行病学研究。
PLoS One. 2015 May 6;10(5):e0125853. doi: 10.1371/journal.pone.0125853. eCollection 2015.
5
Differential modulation of immune response and cytokine profiles in the bursae and spleen of chickens infected with very virulent infectious bursal disease virus.超强毒力传染性法氏囊病病毒感染鸡的法氏囊和脾脏中免疫反应及细胞因子谱的差异调节
BMC Vet Res. 2015 Mar 25;11:75. doi: 10.1186/s12917-015-0377-x.
6
Naturally occurring reassortant infectious bursal disease virus in northern China.中国北方自然发生的传染性法氏囊病病毒重配株
Virus Res. 2015 May 4;203:92-5. doi: 10.1016/j.virusres.2015.04.003. Epub 2015 Apr 11.
7
Efficient assembly of full-length infectious clone of Brazilian IBDV isolate by homologous recombination in yeast.通过酵母中的同源重组高效组装巴西传染性法氏囊病病毒分离株的全长感染性克隆。
Braz J Microbiol. 2015 Mar 4;45(4):1555-63. doi: 10.1590/s1517-83822014000400054. eCollection 2014.
8
Genetic characterization of South American infectious bursal disease virus reveals the existence of a distinct worldwide-spread genetic lineage.南美传染性法氏囊病病毒的基因特征揭示了一种独特的全球传播基因谱系的存在。
Avian Pathol. 2015;44(3):212-21. doi: 10.1080/03079457.2015.1025696. Epub 2015 Apr 2.
9
Binding of the pathogen receptor HSP90AA1 to avibirnavirus VP2 induces autophagy by inactivating the AKT-MTOR pathway.病原体受体HSP90AA1与禽双RNA病毒VP2的结合通过使AKT-MTOR信号通路失活来诱导自噬。
Autophagy. 2015;11(3):503-15. doi: 10.1080/15548627.2015.1017184.
10
Chicken bone marrow-derived dendritic cells maturation in response to infectious bursal disease virus.鸡骨髓来源的树突状细胞对传染性法氏囊病病毒的应答成熟
Vet Immunol Immunopathol. 2015 Mar 15;164(1-2):51-5. doi: 10.1016/j.vetimm.2014.12.012. Epub 2015 Jan 7.
Zotero 插件