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2 型糖尿病患者微量白蛋白尿与高血压的相关性。

Correlation between Microalbuminuria and Hypertension in Type 2 Diabetic Patients.

机构信息

Dr. Alia Ali, FCPS, Senior Registrar, Department of Medicine, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan.

Dr. Azeem Taj, FCPS, Associate Professor, Department of Medicine, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan.

出版信息

Pak J Med Sci. 2014 May;30(3):511-4. doi: 10.12669/pjms.303.5042.

Abstract

BACKGROUND

Hypertension is commonly found in patients with Diabetic Kidney Disease (DKD). Microalbuminuria is the first clinical sign of involvement of kidneys in patients with type 2 diabetes. Uncontrolled hypertension induces a higher risk of cardiovascular events, including death, increasing proteinuria and progression to kidney disease.

OBJECTIVES

To determine the correlation between microalbuminuria and hypertension and their association with other risk factors in type 2 diabetic patients.

METHODS

One hundred and thirteen type 2 diabetic patients attending the diabetic clinic of Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan were screened for microalbuminuria and raised blood pressure. The study was conducted from November 2012 to June 2013.

RESULTS

Patients were divided into two groups. Group 1, those with normoalbuminuria (n=63) and Group 2, those having microalbuminuria (n=50). Group 2 patients showed higher blood pressure values as compared to Group 1. The results were statistically significant and showed poor glycemic control as a contributing risk factor.

CONCLUSION

The study concluded that there is high frequency of hypertension among type 2 diabetics but still much higher among those having microalbuminuria. So, early recognition of renal dysfunction through detection of microalbuminuria and to start treatment without any delay will confer future protection from end stage renal disease as well as hypertension and its complications in type 2 diabetic patients.

摘要

背景

高血压在糖尿病肾病(DKD)患者中很常见。微量白蛋白尿是 2 型糖尿病患者肾脏受累的第一个临床迹象。未控制的高血压会增加心血管事件的风险,包括死亡、蛋白尿增加和肾脏疾病进展。

目的

确定微量白蛋白尿与高血压之间的相关性及其与 2 型糖尿病患者其他危险因素的关系。

方法

在巴基斯坦拉合尔谢赫扎耶德研究生医学研究所的糖尿病诊所筛选了 113 名 2 型糖尿病患者,以检测微量白蛋白尿和高血压。研究于 2012 年 11 月至 2013 年 6 月进行。

结果

患者分为两组。第 1 组为尿白蛋白正常组(n=63),第 2 组为微量白蛋白尿组(n=50)。与第 1 组相比,第 2 组患者的血压值更高。结果具有统计学意义,并显示出较差的血糖控制是一个危险因素。

结论

研究表明,2 型糖尿病患者中高血压的发生率较高,但微量白蛋白尿患者的发生率更高。因此,通过检测微量白蛋白尿早期发现肾功能障碍,并立即开始治疗,将为 2 型糖尿病患者提供未来免受终末期肾病以及高血压及其并发症的保护。

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本文引用的文献

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Standards of medical care in diabetes--2009.《糖尿病医疗护理标准——2009》
Diabetes Care. 2009 Jan;32 Suppl 1(Suppl 1):S13-61. doi: 10.2337/dc09-S013.
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Time to abandon microalbuminuria?是时候摒弃微量白蛋白尿了吗?
Kidney Int. 2006 Oct;70(7):1214-22. doi: 10.1038/sj.ki.5001729. Epub 2006 Jul 26.

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