甲状腺未分化癌的危险因素。
Risk factors for anaplastic thyroid cancer.
机构信息
Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia.
出版信息
Int J Endocrinol. 2014;2014:815070. doi: 10.1155/2014/815070. Epub 2014 May 18.
Background. Anaplastic thyroid cancer (ATC) is a form of thyroid cancer with very poor prognosis, but is fortunately quite rare. Its aetiology is unknown and not well researched. Aim. The aim of this study was to identify potential risk factors for ATC. Material and Method. Case-control study of 126 ATC patients (77 females and 49 males) and 252 controls individually matched by gender, age, and place of abode. In statistical analysis we used a Cox regression model. Results. Univariate logistic regression showed that the risk factors for ATC are low education level, type B blood group, goitre, other nonthyroid malignancies, diabetes, late menarche, and an early first pregnancy. Multivariate logistic regression analysis showed that independent risk factors for ATC are low education level (OR = 1.42, 95% CI = 1.09-1.86), type B blood group (OR = 2.41, 95% CI = 1.03-5.66), and goitre (OR = 25-33, 95% CI = 5.66-126.65). Conclusion. Independent risk factors for ATC are: low education level, type B blood group, and goitre.
背景
间变性甲状腺癌（ATC）是一种预后极差的甲状腺癌，但所幸较为罕见。其病因尚不清楚，也未得到充分研究。目的：本研究旨在确定 ATC 的潜在危险因素。材料与方法：对 126 例 ATC 患者（77 名女性和 49 名男性）和 252 名按性别、年龄和居住地匹配的对照进行病例对照研究。在统计分析中，我们使用了 Cox 回归模型。结果：单因素 logistic 回归显示，ATC 的危险因素包括教育程度低、B 型血、甲状腺肿、其他非甲状腺恶性肿瘤、糖尿病、初潮晚和首次妊娠早。多因素 logistic 回归分析显示，ATC 的独立危险因素包括教育程度低（OR=1.42，95%CI=1.09-1.86）、B 型血（OR=2.41，95%CI=1.03-5.66）和甲状腺肿（OR=25-33，95%CI=5.66-126.65）。结论：ATC 的独立危险因素包括：教育程度低、B 型血和甲状腺肿。
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