Li Xiufeng, Sarkar Subhendra N, Purdy David E, Briggs Richard W
Department of Radiology and Center for Magnetic Resonance Research, University of Minnesota, 2021 Sixth Street SE, Minneapolis, MN 55455, USA.
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Biomed Res Int. 2014;2014:108691. doi: 10.1155/2014/108691. Epub 2014 May 15.
To facilitate quantification of cerebellum cerebral blood flow (CBF), studies were performed to systematically optimize arterial spin labeling (ASL) parameters for measuring cerebellum perfusion, segment cerebellum to obtain separate CBF values for grey matter (GM) and white matter (WM), and compare FAIR ASST to PICORE. Cerebellum GM and WM CBF were measured with optimized ASL parameters using FAIR ASST and PICORE in five subjects. Influence of volume averaging in voxels on cerebellar grey and white matter boundaries was minimized by high-probability threshold masks. Cerebellar CBF values determined by FAIR ASST were 43.8 ± 5.1 mL/100 g/min for GM and 27.6 ± 4.5 mL/100 g/min for WM. Quantitative perfusion studies indicated that CBF in cerebellum GM is 1.6 times greater than that in cerebellum WM. Compared to PICORE, FAIR ASST produced similar CBF estimations but less subtraction error and lower temporal, spatial, and intersubject variability. These are important advantages for detecting group and/or condition differences in CBF values.
为便于对小脑脑血流量（CBF）进行量化，开展了多项研究，以系统优化用于测量小脑灌注的动脉自旋标记（ASL）参数，分割小脑以获取灰质（GM）和白质（WM）各自的CBF值，并将FAIR ASST与PICORE进行比较。使用FAIR ASST和PICORE，通过优化的ASL参数对5名受试者的小脑GM和WM CBF进行了测量。通过高概率阈值掩码将体素中体积平均对小脑灰质和白质边界的影响降至最低。FAIR ASST测定的小脑CBF值，GM为43.8±5.1 mL/100 g/min，WM为27.6±4.5 mL/100 g/min。定量灌注研究表明，小脑GM的CBF是小脑WM的1.6倍。与PICORE相比，FAIR ASST产生的CBF估计值相似，但减法误差更小，时间、空间和受试者间变异性更低。这些对于检测CBF值的组间和/或条件差异而言是重要优势。
