钙离子载体A23187刺激培养的大鼠库普弗细胞合成血小板活化因子。
Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187.
作者信息
Chao W, Siafaka-Kapadai A, Olson M S, Hanahan D J
机构信息
Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284-7760.
出版信息
Biochem J. 1989 Feb 1;257(3):823-9. doi: 10.1042/bj2570823.
Abstract
Cultured rat Kupffer cells synthesize and release platelet-activating factor (PAF) when stimulated with calcium ionophore A23187. The production of PAF is concentration- and time-dependent and, based upon [3H]serotonin release assays, approx. 1.0 pmol of PAF is formed per 8 x 10(6) cells during 10 min of ionophore stimulation. It is suggested that Kupffer cells are important cellular components which produce and release PAF in order to facilitate communication between hepatic sinusoidal and parenchymal cells. Further, it is suggested that such mediator production in response to reticulo-endothelial cell stimulation causes the hepatic glycogenolytic response previously in the isolated perfused rat liver.
摘要
用钙离子载体A23187刺激时，培养的大鼠库普弗细胞可合成并释放血小板活化因子（PAF）。PAF的产生呈浓度和时间依赖性，基于[3H]血清素释放试验，在离子载体刺激10分钟期间，每8×10(6)个细胞约形成1.0皮摩尔PAF。有人认为，库普弗细胞是产生和释放PAF的重要细胞成分，以促进肝窦状隙细胞与实质细胞之间的通讯。此外，有人认为，这种对网状内皮细胞刺激的介质产生导致了先前在离体灌注大鼠肝脏中的肝糖原分解反应。
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