Teixeira Carolina Guimarães, Duarte Maria do Carmo M B, Prado Cecília Maciel, Albuquerque Emídio Cavalcanti de, Andrade Lívia B
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.
J Pediatr (Rio J). 2014 Nov-Dec;90(6):580-6. doi: 10.1016/j.jped.2014.03.002. Epub 2014 Jun 17.
To evaluate the impact of the chronic kidney disease (CKD) on quality of life, from the children's and their parents' perspective, respiratory muscle strength, lung function, and functional capacity in children and adolescents.
Cross-sectional study of children with CKD aged 8 to 17 years. Those incapable of taking the tests were excluded. After an interview, quality of life by Pediatric Quality of Life Inventory) (PedsQL(TM)), muscular strength, pulmonary function tests, and the 6-minute walking test (6MWT) were applied. Student's t-test, ANOVA (difference in means), and Pearson's coefficient of correlation were used. The level of significance was set at 5%.
Of the 40 patients, the mean distance walked at the 6MWT was 396 meters, and the mean final score at the quality of life test as perceived by the children and parents was 50.9 and 51, respectively. From the children's perspective, the transplanted patients had a higher quality of life score when compared to those undergoing hemodialysis (p<0.001); those who practiced physical activity had better quality of life when compared to the sedentary children (p<0.001). From the children's and the parents' perspectives, the male gender had a higher quality of life score (p<0.05). There was a positive correlation between the distance walked at the 6MWT and age, height, final PedsQL(TM), forced vital capacity (FVC), and forced expiratory volume in the first second (FEV1), as well as a negative correlation between FEV1/FVC and the distance walked.
A significant reduction in the quality of life and the functional capacity was observed in children with CKD, influenced by the type of treatment, gender, and sedentary life style.
从儿童及其父母的角度评估慢性肾脏病（CKD）对儿童和青少年生活质量、呼吸肌力量、肺功能及功能能力的影响。
对8至17岁的CKD儿童进行横断面研究。排除无法进行测试的儿童。经过访谈后，应用儿童生活质量量表（PedsQL™）评估生活质量、进行肌肉力量测试、肺功能测试以及6分钟步行试验（6MWT）。采用学生t检验、方差分析（均值差异）和皮尔逊相关系数。显著性水平设定为5%。
40例患者中，6MWT的平均步行距离为396米，儿童和父母所感知的生活质量测试的平均最终得分分别为50.9和51。从儿童的角度来看，与接受血液透析的患者相比，接受移植的患者生活质量得分更高（p<0.001）；与久坐不动的儿童相比，进行体育活动的儿童生活质量更好（p<0.001）。从儿童和父母的角度来看，男性的生活质量得分更高（p<0.05）。6MWT的步行距离与年龄、身高、最终PedsQL™得分、用力肺活量（FVC）和第1秒用力呼气量（FEV1）呈正相关，而FEV1/FVC与步行距离呈负相关。
观察到CKD儿童的生活质量和功能能力显著下降，受治疗类型、性别和久坐生活方式的影响。
