唾液白细胞介素8在高流行地区鉴别潜在恶性口腔病变和口腔鳞状细胞癌中的诊断效用验证
Validation of the diagnostic utility of salivary interleukin 8 in the differentiation of potentially malignant oral lesions and oral squamous cell carcinoma in a region with high endemicity.
作者信息
Rajkumar K, Nandhini G, Ramya R, Rajashree P, Kumar A Ramesh, Anandan S Nirmala
机构信息
Professor and Head, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.
Assistant Professor, Department of Oral and Maxillofacial Pathology, SRM Dental College, SRM University, Chennai, Tamil Nadu, India.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Sep;118(3):309-19. doi: 10.1016/j.oooo.2014.04.008. Epub 2014 May 6.
OBJECTIVE
To evaluate the clinical utility of salivary interleukin 8 (IL-8) in the differential diagnosis of potentially malignant lesions (PMLs) and oral squamous cell carcinoma (OSCC) in a region with high oral cancer prevalence.
STUDY DESIGN
Saliva and blood samples were collected from 100 participants in each group (OSCC, PMLs, and healthy controls). Serum and salivary IL-8 levels were measured by enzyme-linked immunosorbent assay. The data were subjected to appropriate statistical analysis.
RESULTS
A significant increase in levels of serum and salivary IL-8 was found in OSCC compared with PMLs and healthy controls. Receiver operating characteristic curve analysis found salivary IL-8 to have superior sensitivity in detecting OSCC. A significant increase in IL-8 levels based on the histologic grading of OSCC was also observed.
CONCLUSIONS
This study confirms that salivary IL-8 can be a potent marker that can be used as a tool in the differential diagnosis of PMLs and OSCC.
目的
在口腔癌高发地区评估唾液白细胞介素8（IL-8）在潜在恶性病变（PML）和口腔鳞状细胞癌（OSCC）鉴别诊断中的临床应用价值。
研究设计
每组100名参与者（OSCC组、PML组和健康对照组）采集唾液和血液样本。采用酶联免疫吸附测定法测量血清和唾液中IL-8水平。对数据进行适当的统计分析。
结果
与PML组和健康对照组相比，OSCC组血清和唾液中IL-8水平显著升高。受试者工作特征曲线分析发现唾液IL-8在检测OSCC方面具有更高的敏感性。基于OSCC组织学分级也观察到IL-8水平显著升高。
结论
本研究证实唾液IL-8可作为一种有效的标志物，用作PML和OSCC鉴别诊断的工具。
Zotero 插件