Darnis B, Rode A, Mohkam K, Ducerf C, Mabrut J-Y
Service de chirurgie générale et digestive, transplantation hépatique et intestinale, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103, Grande Rue de la Croix-Rousse, 69004 Lyon, France.
Service de radiologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103, Grande Rue de la Croix-Rousse, 69004 Lyon, France.
J Visc Surg. 2014 Oct;151(5):365-75. doi: 10.1016/j.jviscsurg.2014.05.007. Epub 2014 Jun 18.
Liver tumors bleed rarely; management has changed radically during the last 20years, advancing from emergency surgery with poor results to multidisciplinary management. The first steps are the diagnosis and control of bleeding. Abdominopelvic CT scan should be performed as soon as patient hemodynamics allow. When active bleeding is visualized, arterial embolization, targeted as selectively as possible, is preferable to surgery, which should be reserved for severe hemodynamic instability or failure of interventional radiology. When surgery is unavoidable, abbreviated laparotomy (damage control) with perihepatic packing is recommended. The second step is determination of the etiology and treatment of the underlying tumor. Adenoma and hepatocellular carcinoma (HCC) are the two most frequently encountered tumors in this context. Liver MRI after control of the bleeding episode generally leads to the diagnosis although sometimes the analysis can be difficult because of the hematoma. Prompt resection is indicated for HCC, atypical adenoma or lesions at risk for degeneration to hepatocellular carcinoma. For adenoma with no suspicion of malignancy, it is best to wait for the hematoma to resorb completely before undertaking appropriate therapy.
肝肿瘤很少出血;在过去20年中,其治疗方式发生了根本性变化,从效果不佳的急诊手术发展到多学科管理。首要步骤是诊断和控制出血。一旦患者血流动力学状况允许,应尽快进行腹盆腔CT扫描。当发现有活动性出血时,应尽可能有针对性地进行动脉栓塞,这比手术更可取,手术应仅用于严重血流动力学不稳定或介入放射学治疗失败的情况。若手术不可避免,建议采用简化剖腹术(损伤控制)并进行肝周填塞。第二步是确定潜在肿瘤的病因并进行治疗。在此情况下,腺瘤和肝细胞癌(HCC)是最常遇到的两种肿瘤。出血情况得到控制后进行肝脏MRI检查通常可明确诊断,不过有时由于血肿的存在,分析可能会有困难。对于HCC、非典型腺瘤或有恶变为肝细胞癌风险的病变,应及时进行切除。对于无恶性可疑的腺瘤,最好等待血肿完全吸收后再进行适当治疗。