融合分子机制与进化：生物物理学与进化群体遗传学交叉领域的理论与计算
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics.
作者信息
Serohijos Adrian W R, Shakhnovich Eugene I
机构信息
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138, USA.
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138, USA.
出版信息
Curr Opin Struct Biol. 2014 Jun;26:84-91. doi: 10.1016/j.sbi.2014.05.005. Epub 2014 Jun 19.
The variation among sequences and structures in nature is both determined by physical laws and by evolutionary history. However, these two factors are traditionally investigated by disciplines with different emphasis and philosophy-molecular biophysics on one hand and evolutionary population genetics in another. Here, we review recent theoretical and computational approaches that address the crucial need to integrate these two disciplines. We first articulate the elements of these approaches. Then, we survey their contribution to our mechanistic understanding of molecular evolution, the polymorphisms in coding region, the distribution of fitness effects (DFE) of mutations, the observed folding stability of proteins in nature, and the distribution of protein folds in genomes.
自然界中序列和结构的变异既由物理定律决定，也由进化历史决定。然而，传统上这两个因素是由侧重点和理念不同的学科来研究的——一方面是分子生物物理学，另一方面是进化群体遗传学。在这里，我们回顾了近期的理论和计算方法，这些方法满足了整合这两个学科的迫切需求。我们首先阐述这些方法的要素。然后，我们考察它们对我们在分子进化的机制理解、编码区的多态性、突变的适应性效应分布（DFE）、自然界中观察到的蛋白质折叠稳定性以及基因组中蛋白质折叠的分布等方面所做的贡献。
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