左旋咪唑对频繁复发及激素依赖型儿童肾病综合征的疗效
Efficacy of levamisole in children with frequently relapsing and steroid-dependent nephrotic syndrome.
作者信息
Ekambaram Sudha, Mahalingam Vijayakumar, Nageswaran Prahlad, Udani Amish, Geminiganesan Sangeetha, Priyadarshini Shweta
机构信息
Department of Pediatric Nephrology, Mehta Childrens Hospital, Chennai, India. Correspondence to: Dr M Vijayakumar, Consultant Pediatric Nephrologist, Mehta Children's Hospitals, No.2(e) Mc Nichols Road, 3rd Lane, Chetpet, Chennai 600 031, Tamilnadu, India.
出版信息
Indian Pediatr. 2014 May;51(5):371-3. doi: 10.1007/s13312-014-0419-7.
OBJECTIVE
To assess the efficacy of levamisole in frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome.
STUDY DESIGN
Retrospective analysis of hospital case records.
SETTING
Pediatric nephrology department of a tertiary referral pediatric hospital.
PARTICIPANTS
62 children with frequently relapsing nephrotic syndrome and 35 children with steroid-dependent nephrotic syndrome.
METHODS
Case records of children who were diagnosed as steroid-dependant or frequently-relapsing nephrotic syndrome from June 2004 to June 2011, were reviewed. Levamisole was given daily (2 mg/kg/d) along with tapering doses of alternate day steroids after remission on daily steroids.
RESULTS
Levamisole was effective in 77.3% children with a better (80.6%) efficacy in frequently relapsing nephrotic syndrome. A total of 34 children completed 1 year follow-up post levamisole therapy. The cumulative mean (SD) steroid dose 1-year before therapy was 4109(1154) mg/m2 and 1-year post therapy was 661 (11) mg/m2 (P<0.001). The relapses were also less during the period of post-levamisole therapy.
CONCLUSION
Levamisole is an effective alternative therapy in frequently relapsing and steroid-dependent nephrotic syndrome.
目的
评估左旋咪唑对频繁复发型肾病综合征和激素依赖型肾病综合征的疗效。
研究设计
对医院病例记录进行回顾性分析。
研究地点
一家三级转诊儿科医院的儿科肾病科。
研究对象
62例频繁复发型肾病综合征患儿和35例激素依赖型肾病综合征患儿。
方法
回顾2004年6月至2011年6月期间被诊断为激素依赖型或频繁复发型肾病综合征患儿的病例记录。在每日服用激素缓解后，左旋咪唑与隔日递减剂量的激素一起每日服用（2毫克/千克/天）。
结果
左旋咪唑对77.3%的患儿有效，对频繁复发型肾病综合征的疗效更好（80.6%）。共有34名患儿在左旋咪唑治疗后完成了1年的随访。治疗前1年的累积平均（标准差）激素剂量为4109（1154）毫克/平方米，治疗后1年为661（11）毫克/平方米（P<0.001）。左旋咪唑治疗后期间的复发也较少。
结论
左旋咪唑是频繁复发型和激素依赖型肾病综合征的一种有效替代疗法。
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