Hayashi Koichiro, Nakamura Michihiro, Miki Hirokazu, Ozaki Shuji, Abe Masahiro, Matsumoto Toshio, Sakamoto Wataru, Yogo Toshinobu, Ishimura Kazunori
1. Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. E-mail:
2. Division of Transfusion Medicine, Tokushima University Hospital 2-50-1 Kuramoto-cho, Tokushima, 770-0042, Japan;
Theranostics. 2014 Jun 7;4(8):834-44. doi: 10.7150/thno.9199. eCollection 2014.
We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (T g) of 44°C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44°C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity.
我们报道了一种智能纳米颗粒（NPs）的合成，该颗粒能响应交变电流磁场（ACMF）产生热量，并能顺序释放抗癌药物（阿霉素，DOX）。我们进一步研究了使用这种智能纳米颗粒进行磁热疗（MHT）与化疗联合治疗多发性骨髓瘤的体内治疗效果。这种智能纳米颗粒由玻璃化转变温度（Tg）为44°C的聚合物组成，其中包含聚集的Fe3O4纳米颗粒和DOX。当施加ACMF时，聚集的Fe3O4纳米颗粒产生热量并升至44°C以上，这会使聚合物相软化并导致DOX释放。使用这种智能纳米颗粒进行MHT与化疗联合治疗可破坏整个肿瘤中的癌细胞，并在一次治疗中实现完全治愈且无恶性肿瘤复发。此外，这种智能纳米颗粒没有明显的毒性。
