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基于纳米平台的癌症诊断成像的当前趋势与进展

Current Trends and Advances in Nanoplatforms-Based Imaging for Cancer Diagnosis.

作者信息

Umadevi Kovuri, Sundeep Dola, Vighnesh Alluru Raghavendra, Misra Aroonima, Krishna Alluru Gopala

机构信息

Department of Pathology, Government Medical College and Hospital, Khaleelwadi, Nizamabad, Telangana 503001 India.

Biomedical Research Laboratory, Department of Electronics and Communication Engineering, Indian Institute of Information Technology Design and Manufacturing, Jagannathagattu Hill, Kurnool, Andhra Pradesh 518008 India.

出版信息

Indian J Microbiol. 2025 Mar;65(1):137-176. doi: 10.1007/s12088-024-01373-9. Epub 2024 Aug 9.


DOI:10.1007/s12088-024-01373-9
PMID:40371042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12069201/
Abstract

The intersection of nanotechnology and biomedical imaging has ushered in a new era in the early detection and diagnosis of cancer which has revolutionized biomedical imaging by enhancing sensitivity, resolution, and targeting capability. This review presents a comprehensive overview of the latest developments and innovations in nanoplatforms-based imaging for cancer diagnosis, a burgeoning field that holds significant potential in improving cancer detection and treatment. Recently multimodal imaging techniques utilizing the unique properties of different types of nanoparticles are providing comprehensive diagnostic information. This multi-pronged approach allows for more precise tumor localization, size estimation, and growth rate calculation, offering a holistic view of the tumor and its environment. The primary focus of this review is on the recent progress in various types of nanoparticle-based imaging modalities, including optical, magnetic resonance, ultrasound, and nuclear imaging. Specific advancements in nanomaterial design for targeted imaging are highlighted, showing the improvement of precision targeting as an impact on the detection of cancer cells, even in early-stage tumors. A keen examination on the integration of diagnostic and therapeutic capabilities into single nano-based platforms for theranostics, underscoring their potential in personalized medicine is provided. The current challenges in the field, such as issues related to toxicity, biodistribution, and clearance of nanoparticles, and it explores ongoing research aimed at overcoming these hurdles. The growing body of research in this field highlights the promising future of nanoplatforms in improving the early detection and treatment of cancer.

摘要

纳米技术与生物医学成像的交叉融合开创了癌症早期检测与诊断的新时代,通过提高灵敏度、分辨率和靶向能力,彻底改变了生物医学成像。本综述全面概述了基于纳米平台的癌症诊断成像的最新进展与创新,这一新兴领域在改善癌症检测与治疗方面具有巨大潜力。最近,利用不同类型纳米颗粒的独特性质的多模态成像技术正在提供全面的诊断信息。这种多管齐下的方法能够实现更精确的肿瘤定位、大小估计和生长速率计算,提供肿瘤及其周围环境的整体视图。本综述的主要重点是各种基于纳米颗粒的成像模态的最新进展,包括光学成像、磁共振成像、超声成像和核成像。突出了用于靶向成像的纳米材料设计的具体进展,显示出精确靶向的改善对癌细胞检测的影响,即使在早期肿瘤中也是如此。对将诊断和治疗能力整合到用于治疗诊断的单一纳米平台进行了深入研究,强调了它们在个性化医疗中的潜力。探讨了该领域当前面临的挑战,如与纳米颗粒的毒性、生物分布和清除相关的问题,并探索了旨在克服这些障碍的正在进行的研究。该领域不断增加的研究成果凸显了纳米平台在改善癌症早期检测和治疗方面的光明前景。

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本文引用的文献

[1]
Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials.

Molecules. 2023-6-30

[2]
What function of nanoparticles is the primary factor for their hyper-toxicity?

Adv Colloid Interface Sci. 2023-4

[3]
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Int J Mol Sci. 2023-2-5

[4]
Nanoparticles labeled with gamma-emitting radioisotopes: an attractive approach for in vivo tracking using SPECT imaging.

Drug Deliv Transl Res. 2023-6

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Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer.

Pharmaceutics. 2023-1-11

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Nanotechnology: A Revolution in Modern Industry.

Molecules. 2023-1-9

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Nanomaterials (Basel). 2022-12-19

[8]
Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy.

Sci Rep. 2022-12-1

[9]
The Application of Nanotechnology and Nanomaterials in Cancer Diagnosis and Treatment: A Review.

Cureus. 2022-9-11

[10]
In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications.

J Nanobiotechnology. 2022-10-15

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