Li Xiaoyi, Wu Hao, Lou Cen, Xing Baoping, Yu Enyan
Department of Psychiatry and Mental Health, Tongde Hospital of Zhejiang Province Hangzhou 310012, China ; The Mental Health Institute of Zhejiang Province Hangzhou 310012, China.
Department of Psychiatry and Mental Health, Affiliated Sir Run Run Shaw Hospital, Medical School of Zhejiang University Hangzhou 310016, China ; Sir Run Run Shaw Institute, Clinical Medicine of Zhejiang University Hangzhou 310016, China.
Int J Clin Exp Med. 2014 Apr 15;7(4):1110-5. eCollection 2014.
To investigate event-related potential in executive function of attention and characteristics of cerebral perfusion by 99mTc-ECD single-photon emission computed tomography (SPECT) in depression patients receiving the Oddball task.
A total of 30 depression patients and 30 normal control subjects were selected to carry out the Oddball task. Event-related potential (ERP) technology combined with SPECT imaging technology was used to compare the reaction time, ERP-P300 latency and amplitude, and cerebral perfusion characteristics on sites of brain.
Compared with normal control group, when the Oddball task was performed, the reaction time or ERP-P300 latency was not significantly different in depression patients (P > 0.05), but P300 amplitude on F3 and F7 sites increased significantly (t = 2.241, 2.245, respectively; each P < 0.05). SPECT showed cerebral hypoperfusion in the right basal ganglia, left frontal lobe and temporal lobe of depression patients.
During the Oddball task, the P300 amplitude on F3 and F7 sites increased significantly in depression patients, who also showed cerebral hypoperfusion in the right basal ganglia, left frontal lobe and temporal lobe. The result suggests that depression patients have brain region functional abnormalities involving attention execution and implicit memory processing during auditory channel information processing.
采用99mTc-ECD单光子发射计算机断层扫描（SPECT）研究抑郁症患者在Oddball任务中执行注意功能的事件相关电位及脑灌注特征。
选取30例抑郁症患者和30例正常对照者进行Oddball任务。采用事件相关电位（ERP）技术结合SPECT成像技术，比较反应时间、ERP-P300潜伏期和波幅以及脑区的脑灌注特征。
与正常对照组相比，抑郁症患者在执行Oddball任务时，反应时间或ERP-P300潜伏期差异无统计学意义（P>0.05），但F3和F7位点的P300波幅显著增加（t分别为2.241、2.245；P均<0.05）。SPECT显示抑郁症患者右侧基底节、左侧额叶和颞叶脑灌注减低。
在Oddball任务中，抑郁症患者F3和F7位点的P300波幅显著增加，且右侧基底节、左侧额叶和颞叶脑灌注减低。结果提示，抑郁症患者在听觉通道信息处理过程中存在涉及注意执行和内隐记忆加工的脑区功能异常。
