Cui Ran, Su Bin, Sheng Chunjun, Cheng Xiaoyun, Yang Peng, Bu Le, Li Hong, Wang Jiying, Sheng Hui, Qu Shen
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China ; Advanced Institute of Translational Medicine, Tongji University Shanghai 200092, China.
Int J Clin Exp Med. 2014 Apr 15;7(4):1145-9. eCollection 2014.
To investigate the relationship between total osteocalcin (total OC) and testosterone level in the serum of male patients with type 2 diabetes mellitus (T2DM).
98 male T2DM were recruited in our cross-section study. Their anthropometric parameters were measured and body mass index (BMI) was calculated. Serum markers including glucose, insulin, HbA1c, testosterone, total OC and other bone metabolic markers were examined. Simple Pearson correlation and multiple regression analysis were performed.
Poor level of glucose control was found in the patients (HbA1c 9.19±2.53 and FPG 8.20±2.98). In simple Pearson correlation, total OC was positively related with testosterone (r=0.236, P=0.019), and this relation still existed after considering all the parameters of the patients (Model 1, 2 and 3).
In male patients with T2DM, total OC was positively correlated with testosterone, so total OC might predict the testosterone level in the serum.
探讨2型糖尿病（T2DM）男性患者血清中总骨钙素（total OC）与睾酮水平之间的关系。
在我们的横断面研究中招募了98例男性T2DM患者。测量他们的人体测量参数并计算体重指数（BMI）。检测血清标志物，包括血糖、胰岛素、糖化血红蛋白（HbA1c）、睾酮、总骨钙素及其他骨代谢标志物。进行简单Pearson相关性分析和多元回归分析。
患者血糖控制水平较差（HbA1c为9.19±2.53，空腹血糖（FPG）为8.20±2.98）。在简单Pearson相关性分析中，总骨钙素与睾酮呈正相关（r = 0.236，P = 0.019），在考虑患者所有参数后这种关系仍然存在（模型1、2和3）。
在男性T2DM患者中，总骨钙素与睾酮呈正相关，因此总骨钙素可能预测血清中的睾酮水平。
