Qasemzadeh Mohammad Javad, Fathi Mahdi, Tashvighi Maryam, Gharehbeglou Mohammad, Yadollah-Damavandi Soheila, Parsa Yekta, Rahimi Ebrahim
Department of Medicine, Islamic Azad University, Qom Branch, Qom, Iran.
Students' Research Committee, Islamic Azad University, Tehran Medical Branch, Tehran, Iran.
Scientifica (Cairo). 2014;2014:694193. doi: 10.1155/2014/694193. Epub 2014 May 12.
Objectives. Pneumonia is one of the common mortality causes in young children. Some studies have shown beneficial effect of zinc supplements on treatment of pneumonia. The present study aimed to investigate the effects of short courses of zinc administration on recovery from this disease in hospitalized children. Methods. In a parallel Double-Blind Randomized Controlled Trial at Ayatollah Golpaygani Hospital in Qom, 120 children aged 3-60 months with pneumonia were randomly assigned 1 : 1 to receive zinc or placebo (5 mL every 12 hours) along with the common antibiotic treatments until discharge. Primary outcome was recovery from pneumonia which included the incidence and resolving clinical symptoms and duration of hospitalization. Results. The difference between two groups in all clinical symptoms at admittance and the variables affecting the disease such as age and sex were not statistically significant (P < 0.05) at baseline. Compared to the placebo group, the treatment group showed a statistically significant decrease in duration of clinical symptoms (P = 0.044) and hospitalization (P = 0.004). Conclusions. Supplemental administration of zinc can expedite the healing process and results in faster resolution of clinical symptoms in children with pneumonia. In general, zinc administration, along with common antibiotic treatments, is recommended in this group of children. It can also reduce the drug resistance caused by multiple antibiotic therapies. This trial is approved by Medical Ethic Committee of Islamic Azad University in Iran (ID Number: 8579622-Q). This study is also registered in AEARCTR (The American Economic Association's Registry for Randomized Controlled Trials). This trial is registered with RCT ID: AEARCTR-0000187.
目的。肺炎是幼儿常见的死亡原因之一。一些研究表明锌补充剂对肺炎治疗有有益作用。本研究旨在调查短期补锌对住院儿童肺炎康复的影响。方法。在库姆阿亚图拉·戈尔帕甘尼医院进行的一项平行双盲随机对照试验中，120名3至60个月大的肺炎患儿被随机分为1∶1两组，在接受常规抗生素治疗直至出院的同时，分别接受锌或安慰剂治疗（每12小时5毫升）。主要结局是肺炎康复情况，包括临床症状的发生率、缓解情况及住院时间。结果。两组在入院时的所有临床症状以及影响疾病的变量如年龄和性别方面，基线时差异无统计学意义（P<0.05）。与安慰剂组相比，治疗组临床症状持续时间（P = 0.044）和住院时间（P = 0.004）有统计学意义的显著缩短。结论。补充锌可加快肺炎患儿的愈合过程，使临床症状更快缓解。总体而言，建议在这类儿童中补锌并同时进行常规抗生素治疗。它还可降低多种抗生素治疗引起的耐药性。本试验已获伊朗伊斯兰阿扎德大学医学伦理委员会批准（编号：8579622-Q）。本研究也已在AEARCTR（美国经济协会随机对照试验注册库）注册。本试验注册号为：AEARCTR-0000187。
