• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

L-抗坏血酸内酯衍生物的合成

Synthesis of l-Ascorbic Acid Lactone Derivatives.

作者信息

Shao Li-Dong, Wu Ya-Nan, Xu Jun, He Juan, Zhao Yu, Peng Li-Yan, Li Yan, Yang Yu-Rong, Xia Cheng-Feng, Zhao Qin-Shi

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China ; Graduate School of the Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, 100049 China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.

出版信息

Nat Prod Bioprospect. 2014 Jun;4(3):181-8. doi: 10.1007/s13659-014-0022-6. Epub 2014 May 21.

DOI:10.1007/s13659-014-0022-6
PMID:24955300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4050306/
Abstract

A small focused library which comprised of l-AA lactone derivatives was built with a facile method. This reported method was optimized by modifying the acidity of the solvent. As a result, 12 l-AA lactones were synthesized. Among these lactones, lactones 8-12 were new compounds. The cytotoxicity of these synthetic compounds were investigated.

摘要

通过一种简便的方法构建了一个由L-AA内酯衍生物组成的小型聚焦库。通过改变溶剂的酸度对该报道的方法进行了优化。结果，合成了12种L-AA内酯。在这些内酯中，内酯8-12是新化合物。对这些合成化合物的细胞毒性进行了研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/0d23029b306e/13659_2014_22_Article_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/b5d6bb886670/13659_2014_22_Article_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/8a2be9881ae7/13659_2014_22_Article_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/4a905df9d95b/13659_2014_22_Article_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/0d23029b306e/13659_2014_22_Article_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/b5d6bb886670/13659_2014_22_Article_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/8a2be9881ae7/13659_2014_22_Article_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/4a905df9d95b/13659_2014_22_Article_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7521/4131365/0d23029b306e/13659_2014_22_Article_Sch2_HTML.jpg

相似文献

1
Synthesis of l-Ascorbic Acid Lactone Derivatives.L-抗坏血酸内酯衍生物的合成
Nat Prod Bioprospect. 2014 Jun;4(3):181-8. doi: 10.1007/s13659-014-0022-6. Epub 2014 May 21.
2
L-ascorbic acid biosynthesis in higher plants from L-gulono-1, 4-lactone and L-galactono-1, 4-lactone.高等植物中由L-古洛糖酸-1,4-内酯和L-半乳糖酸-1,4-内酯合成L-抗坏血酸
Plant Physiol. 1970 Aug;46(2):277-80. doi: 10.1104/pp.46.2.277.
3
A convenient entry to C2- and C3-substituted gulono-gamma-lactone derivatives from L-ascorbic acid.从L-抗坏血酸便捷合成C2-和C3-取代古洛糖酸-γ-内酯衍生物的方法。
J Org Chem. 2005 Aug 19;70(17):6782-9. doi: 10.1021/jo0508550.
4
The biosynthetic pathway of L-ascorbic acid in Euglena gracilis Z.纤细裸藻中L-抗坏血酸的生物合成途径
J Nutr Sci Vitaminol (Tokyo). 1979;25(4):299-307. doi: 10.3177/jnsv.25.299.
5
Synthesis of L-ascorbic acid in rat-liver homogenates. Conversion of L-gulono- and L-galactono-gamma-lactone and the respective acids into L-ascorbic acid.大鼠肝脏匀浆中L-抗坏血酸的合成。L-古洛糖酸-γ-内酯和L-半乳糖酸-γ-内酯以及相应的酸转化为L-抗坏血酸。
Biochem J. 1960 Jul;76(1):157-71. doi: 10.1042/bj0760157.
6
The synthesis of strigolactone is affected by endogenous ascorbic acid in transgenic rice for l-galactono-1, 4-lactone dehydrogenase suppressed or overexpressing.内源抗坏血酸影响转基因水稻中 l-半乳糖酸-1,4-内酯脱氢酶抑制或过表达的独脚金内酯合成。
J Plant Physiol. 2020 Mar-Apr;246-247:153139. doi: 10.1016/j.jplph.2020.153139. Epub 2020 Feb 22.
7
Effect of mitochondrial ascorbic acid synthesis on photosynthesis.线粒体抗坏血酸合成对光合作用的影响。
Plant Physiol Biochem. 2016 Jul;104:29-35. doi: 10.1016/j.plaphy.2016.03.012. Epub 2016 Mar 10.
8
Synthetic studies of (23S,25R)-1α,25-dihydroxyvitamin D 26,23-lactone (calcitriol lactone) and its derivatives.（23S，25R）-1α，25-二羟维生素 D26，23-内酯（骨化三醇内酯）及其衍生物的合成研究。
J Steroid Biochem Mol Biol. 2018 Mar;177:240-246. doi: 10.1016/j.jsbmb.2017.07.017. Epub 2017 Jul 27.
9
Conversion of L-galactono-gamma-lactone into L-ascorbic acid by plants.植物将L-半乳糖酸-γ-内酯转化为L-抗坏血酸的过程。
Nature. 1961 Jul 15;191:282-3. doi: 10.1038/191282a0.
10
The new 5- or 6-azapyrimidine and cyanuric acid derivatives of l-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic spacer: CD-spectral absolute configuration determination and biological activity evaluations.在烯键间隔基上带有游离C-5羟基或C-4氨基的L-抗坏血酸的新型5-或6-氮杂嘧啶与氰尿酸衍生物：圆二色光谱法测定绝对构型及生物活性评估
Eur J Med Chem. 2011 Jul;46(7):2770-85. doi: 10.1016/j.ejmech.2011.03.066. Epub 2011 Apr 6.

引用本文的文献

1
Bromophenolics from the Red Alga .红藻中的溴酚类化合物
Mar Drugs. 2019 Aug 26;17(9):497. doi: 10.3390/md17090497.
2
Synthesis and Cytotoxicity Evaluation of Tropinone Derivatives.托品酮衍生物的合成与细胞毒性评价
Nat Prod Bioprospect. 2017 Apr;7(2):215-223. doi: 10.1007/s13659-017-0124-z. Epub 2017 Mar 20.
3
Solid-Phase Synthesis of ɤ-Lactone and 1,2-Oxazine Derivatives and Their Efficient Chiral Analysis.γ-内酯和1,2-恶嗪衍生物的固相合成及其高效手性分析

本文引用的文献

1
Lycospidine A, a new type of Lycopodium alkaloid from Lycopodium complanatum.石松 A，一种来自石松属 complanatum 的新型石松生物碱。
Org Lett. 2013 May 17;15(10):2438-41. doi: 10.1021/ol400907v. Epub 2013 May 6.
2
Organocatalytic 1,4-conjugate addition of ascorbic acid to α,β-unsaturated aldehydes: bio-inspired total syntheses of leucodrin, leudrin and proposed structure of dilaspirolactone.有机催化抗坏血酸对α,β-不饱和醛的 1,4-共轭加成：生物启发的白屈菜红碱、白屈菜赤碱和二拉西罗内酯的提议结构的全合成。
Org Biomol Chem. 2013 Apr 7;11(13):2093-7. doi: 10.1039/c3ob00046j.
3
Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua.
PLoS One. 2016 Nov 28;11(11):e0166558. doi: 10.1371/journal.pone.0166558. eCollection 2016.
石松甲素 A，一种新型结构拥挤的石松生物碱，具有前所未有的骨架，来源于穗花杉。
Chem Commun (Camb). 2012 Sep 18;48(72):9038-40. doi: 10.1039/c2cc34676a. Epub 2012 Aug 2.
4
Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit.比较评价从枸杞果中分离得到的天然维生素 C 类似物 2-O-β-D-吡喃葡萄糖基-L-抗坏血酸的抗氧化作用。
Arch Pharm Res. 2011 May;34(5):801-10. doi: 10.1007/s12272-011-0514-4. Epub 2011 Jun 9.
5
Covalent interaction of ascorbic acid with natural products.抗坏血酸与天然产物的共价相互作用。
Phytochemistry. 2009 Dec;70(17-18):1930-9. doi: 10.1016/j.phytochem.2009.09.028. Epub 2009 Oct 28.
6
Lycojapodine A, a novel alkaloid from Lycopodium japonicum.石松碱甲，一种从日本石松中提取的新型生物碱。
Org Lett. 2009 Mar 19;11(6):1397-400. doi: 10.1021/ol900079t.
7
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.新型C-5取代嘧啶和呋喃并[2,3-d]嘧啶4',5'-二脱氢-L-抗坏血酸衍生物的合成、抗病毒及细胞生长抑制活性评价
J Med Chem. 2007 Aug 23;50(17):4105-12. doi: 10.1021/jm070324z. Epub 2007 Aug 2.
8
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.新型L-抗坏血酸的C-5芳基、烯基和炔基取代尿嘧啶衍生物：合成、细胞抑制及抗病毒活性评估
Bioorg Med Chem. 2007 Jan 15;15(2):749-58. doi: 10.1016/j.bmc.2006.10.046. Epub 2006 Oct 25.
9
Dichotomains A and B: two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma.二歧域A和B：来自芒萁的两种新的高氧化酚类衍生物。
Org Lett. 2006 Apr 27;8(9):1937-40. doi: 10.1021/ol060535i.
10
The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation.新型L-抗坏血酸嘧啶和嘌呤衍生物：合成、一维及二维氢谱和碳谱研究、细胞抑制和抗病毒评估
Bioorg Med Chem. 2005 Jan 3;13(1):131-9. doi: 10.1016/j.bmc.2004.09.052.