School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476V Melbourne, VIC 3001, Australia.
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia.
Mar Drugs. 2019 Aug 26;17(9):497. doi: 10.3390/md17090497.
The isolation and the structure determination of a new bromophenolic compound, polysiphonol (), as well as five previously reported compounds, (-), from the red alga is reported. In addition, the absolute configuration of the natural product rhodomelol () could be unequivocally confirmed for the first time, and on biosynthetic grounds, the absolute configuration of polysiphonol () was tentatively suggested. Compounds - were evaluated for their antibacterial activity against both Gram-positive and Gram-negative bacteria, but none of the compounds showed any appreciable activity.
从红藻中分离得到一种新的溴酚化合物,多缩酚(),并对其结构进行了测定,同时还分离得到了另外五种先前报道过的化合物,(-)。此外,首次明确确定了天然产物 rhodomelol()的绝对构型,并根据生物合成的原因,暂定推测了多缩酚()的绝对构型。对化合物 - 进行了抗革兰氏阳性菌和革兰氏阴性菌的抗菌活性评价,但没有一种化合物表现出明显的活性。