构建用于脑和脊髓组织工程的生物相容性水凝胶。
Building biocompatible hydrogels for tissue engineering of the brain and spinal cord.
作者信息
Aurand Emily R, Wagner Jennifer, Lanning Craig, Bjugstad Kimberly B
机构信息
Neuroscience Program and Department of Pediatrics, University of Colorado-Denver, Anschutz Medical Campus, Mail Stop 8313, 12800 E. 19th Avenue, Aurora, CO 80045, USA.
Department of Bioengineering, University of Colorado-Denver, Anschutz Medical Campus, Mail Stop 8607, 12700 E. 19th Avenue, Aurora, CO 80045, USA.
出版信息
J Funct Biomater. 2012 Nov 15;3(4):839-63. doi: 10.3390/jfb3040839.
Tissue engineering strategies employing biomaterials have made great progress in the last few decades. However, the tissues of the brain and spinal cord pose unique challenges due to a separate immune system and their nature as soft tissue. Because of this, neural tissue engineering for the brain and spinal cord may require re-establishing biocompatibility and functionality of biomaterials that have previously been successful for tissue engineering in the body. The goal of this review is to briefly describe the distinctive properties of the central nervous system, specifically the neuroimmune response, and to describe the factors which contribute to building polymer hydrogels compatible with this tissue. These factors include polymer chemistry, polymerization and degradation, and the physical and mechanical properties of the hydrogel. By understanding the necessities in making hydrogels biocompatible with tissue of the brain and spinal cord, tissue engineers can then functionalize these materials for repairing and replacing tissue in the central nervous system.
在过去几十年中，采用生物材料的组织工程策略取得了巨大进展。然而，由于独特的免疫系统以及作为软组织的性质，脑和脊髓组织带来了独特的挑战。因此，用于脑和脊髓的神经组织工程可能需要重新建立生物材料的生物相容性和功能，这些生物材料此前在体内组织工程中已取得成功。本综述的目的是简要描述中枢神经系统的独特特性，特别是神经免疫反应，并描述有助于构建与该组织相容的聚合物水凝胶的因素。这些因素包括聚合物化学、聚合和降解，以及水凝胶的物理和机械性能。通过了解使水凝胶与脑和脊髓组织生物相容的必要性，组织工程师随后可以对这些材料进行功能化，以修复和替换中枢神经系统中的组织。
Zotero 插件