Hejcl A, Lesný P, Prádný M, Michálek J, Jendelová P, Stulík J, Syková E
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Physiol Res. 2008;57 Suppl 3:S121-S132. doi: 10.33549/physiolres.931606. Epub 2008 May 13.
Spinal cord injury results in a permanent neurological deficit due to tissue damage. Such a lesion is a barrier for "communication" between the brain and peripheral tissues, effectors as well as receptors. One of the primary goals of tissue engineering is to bridge the spinal cord injury and re-establish the damaged connections. Hydrogels are biocompatible implants used in spinal cord injury repair. They can create a permissive environment and bridge the lesion cavities by providing a scaffold for the regeneration of neurons and their axons, glia and other tissue elements. The advantage of using artificial materials is the possibility to modify their physical and chemical properties in order to develop the best implant suitable for spinal cord injury repair. As a result, several types of hydrogels have been tested in experimental studies so far. We review our work that has been done during the last 5 years with various types of hydrogels and their applications in experimental spinal cord injury repair.
脊髓损伤会因组织损伤导致永久性神经功能缺损。这种损伤是大脑与外周组织、效应器以及感受器之间“通讯”的障碍。组织工程的主要目标之一是修复脊髓损伤并重建受损连接。水凝胶是用于脊髓损伤修复的生物相容性植入物。它们可以创造一个有利的环境，并通过为神经元及其轴突、神经胶质细胞和其他组织成分的再生提供支架来桥接损伤腔。使用人工材料的优点是可以改变其物理和化学性质，以开发出最适合脊髓损伤修复的植入物。因此，到目前为止，已有几种类型的水凝胶在实验研究中得到测试。我们回顾了过去5年中我们使用各种类型水凝胶及其在实验性脊髓损伤修复中的应用所开展的工作。
