D'Souza Vandita, Patil Vidya, Pisal Hemlata, Randhir Karuna, Joshi Asmita, Mehendale Savita, Wagh Girija, Gupte Sanjay, Joshi Sadhana
Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, India.
Department of Obstetrics and Gynaecology, Bharati Medical College and Hospital, Bharati Vidyapeeth University, Pune, India.
Int J Dev Neurosci. 2014 Oct;37:36-40. doi: 10.1016/j.ijdevneu.2014.06.008. Epub 2014 Jun 20.
Preeclampsia (PE) is a major pregnancy complication of placental origin which leads to adverse pregnancy outcome. Brain derived neurotrophic factor (BDNF) is suggested to promote trophoblast growth and regulate placental and fetal development. This study for the first time examines the levels of maternal plasma BDNF at various time points during gestation, cord plasma and placental BDNF levels and their association with birth outcome in women with PE. Normotensive control (NC) women (n=89) and women with PE (n=61) were followed at three different time points [16-20 weeks (T1), 26-30 weeks (T2) and at delivery (T3)]. Maternal blood at all time points and cord blood was collected. Results indicate that maternal BDNF levels at T1 (p=0.050) and T3 (p=0.025) were lower in women with PE than in NC women. Cord BDNF levels at delivery in women with PE were lower (p=0.032) than those in NC women. Placental BDNF gene expression was also lower (p=0.0082) in women with PE than in NC women. Our data suggests that BDNF plays an important role in the development of the materno-fetal-placental unit during pregnancy. Alteration in the levels of BDNF during pregnancy may be associated with an abnormal development of the placenta resulting in PE.
子痫前期（PE）是一种主要源于胎盘的妊娠并发症，会导致不良妊娠结局。脑源性神经营养因子（BDNF）被认为可促进滋养层生长并调节胎盘和胎儿发育。本研究首次检测了妊娠期不同时间点孕妇血浆BDNF水平、脐血和胎盘BDNF水平，以及它们与PE患者分娩结局的关联。对血压正常的对照（NC）组女性（n = 89）和PE组女性（n = 61）在三个不同时间点进行随访，即妊娠16 - 20周（T1）、26 - 30周（T2）和分娩时（T3）。采集所有时间点的孕妇血液和脐血。结果表明，PE组女性在T1（p = 0.050）和T3（p = 0.025）时的母体BDNF水平低于NC组女性。PE组女性分娩时的脐血BDNF水平低于（p = 0.032）NC组女性。PE组女性的胎盘BDNF基因表达也低于（p = 0.0082）NC组女性。我们的数据表明，BDNF在孕期母胎 - 胎盘单位的发育中起重要作用。孕期BDNF水平的改变可能与胎盘发育异常导致PE有关。
