Medical University of Innsbruck, Department of Anesthesiology and Critical Care Medicine, Innsbruck, 6020, Austria.
Medical University of Innsbruck, Department of Gynecology and Obstetrics, Innsbruck, 6020, Austria.
Sci Rep. 2020 Apr 1;10(1):5783. doi: 10.1038/s41598-020-62805-2.
During pregnancy, substantial alterations in cerebral plasticity, vascular remodeling and neuronal growth occur in the maternal brain. We investigated whether concentrations of selected neurodiagnostic biomarkers in the cerebrospinal fluid of women with preeclampsia/HELLP syndrome differ from those in healthy controls using enzyme-linked immunosorbent assay technique. We found that tau protein concentrations (p = 0.016) and phospho-tau/tau ratio (p < 0.001) in cerebrospinal fluid were significantly lower in 39 preeclamptic women compared to 44 healthy controls during third trimester of pregnancy. Beta-amyloid(1-40)/(1-42) ratio was significantly higher in HELLP syndrome than in severe preeclampsia (8.49 + 2.73 vs. 4.71 + 1.65; p = 0.007). We conclude that beta-amyloid(1-40)/(1-42) ratio in cerebrospinal fluid can discriminate severe preeclampsia and HELLP syndrome. High beta-amyloid peptide and low tau protein concentrations are associated with impaired development of the materno-feto-placental unit and correlate with placental dysfunction.
在妊娠期间，母体大脑中的脑可塑性、血管重塑和神经元生长会发生实质性改变。我们使用酶联免疫吸附测定技术研究了子痫前期/HELLP 综合征妇女脑脊液中选定神经诊断生物标志物的浓度是否与健康对照组不同。我们发现，与 44 名健康对照组相比，39 名子痫前期妇女在妊娠晚期脑脊液中的 tau 蛋白浓度（p=0.016）和磷酸化 tau/tau 比值（p<0.001）显著降低。HELLP 综合征中的β-淀粉样蛋白(1-40)/(1-42)比值明显高于严重子痫前期（8.49+2.73 对 4.71+1.65；p=0.007）。我们得出结论，脑脊液中的β-淀粉样蛋白(1-40)/(1-42)比值可以区分严重子痫前期和 HELLP 综合征。高β-淀粉样肽和低 tau 蛋白浓度与母胎胎盘单位发育受损有关，并与胎盘功能障碍相关。
