Department of Orthopaedic Surgery, University of Toledo Health Science Campus, Toledo, OH 43614, United States; Department of Physiology and Pharmacology, University of Toledo Health Science Campus, Toledo, OH 43614, United States; Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, OH 43614, United States.
Department of Orthopaedic Surgery, University of Toledo Health Science Campus, Toledo, OH 43614, United States; Center for Diabetes and Endocrine Research, University of Toledo Health Science Campus, Toledo, OH 43614, United States.
Arch Biochem Biophys. 2014 Nov 1;561:124-9. doi: 10.1016/j.abb.2014.06.010. Epub 2014 Jun 20.
Environmental and behavioral changes which occurred over the last century led simultaneously to a remarkable increase in human lifespan and to the development of health problems associated with functional impairment of organs either regulating or dependent on balanced energy metabolism. Diseases such as diabetes, obesity and osteoporosis are prevalent in our society and pose major challenges with respect to the overall health and economy. Therefore, better understanding of regulatory axes between bone and fat may provide the basis for development of strategies which will treat these diseases simultaneously and improve health and life quality of elderly.
上个世纪发生的环境和行为变化，同时导致人类寿命的显著延长和与调节或依赖平衡能量代谢的器官功能障碍相关的健康问题的发展。在我们的社会中，糖尿病、肥胖症和骨质疏松症等疾病很常见，给整体健康和经济带来了重大挑战。因此，更好地理解骨骼和脂肪之间的调节轴可能为开发同时治疗这些疾病并改善老年人健康和生活质量的策略提供基础。
