Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road Grafton, Auckland, New Zealand.
Curr Osteoporos Rep. 2018 Apr;16(2):116-122. doi: 10.1007/s11914-018-0425-0.
The goal of this review is to gain a better understanding of marrow adipocyte development, its regulation of energy, and its characterization responsible for bone homeostasis.
Despite major advances in uncovering the complex association of bone-fat in the marrow, the underlying basic biological process of adipose tissue development, as well as its interaction with bone homeostasis in pathophysiological conditions, is still not well understood. This review identifies many pro- and anti-osteogenic factors secreted by adipocytes to play a role in the manipulating the fate of mesenchymal stem cells as well as the osteoblastic activity during bone remodeling. It also addresses the function of adipose tissue capable of negative regulation of the hematopoietic microenvironment to influence the bone quantity and the nature of bone homeostasis.
本篇综述的目的是更好地了解骨髓脂肪细胞的发育、其对能量的调节以及对维持骨稳态负责的特征。
尽管在揭示骨髓中骨-脂肪的复杂关联方面取得了重大进展，但脂肪组织发育的基本生物学过程及其在病理生理条件下与骨稳态的相互作用仍未得到很好的理解。 本篇综述确定了许多由脂肪细胞分泌的促和成骨因子，这些因子在调节间充质干细胞的命运以及骨重塑过程中的成骨细胞活性方面发挥作用。 它还涉及脂肪组织的功能，能够负向调节造血微环境，从而影响骨量和骨稳态的性质。
