Departamento de Química, Universidade Federal de Sergipe, 49100-000 São Cristóvão, SE, Brazil.
Nat Prod Res. 2013;27(11):997-1001. doi: 10.1080/14786419.2012.686913. Epub 2012 May 15.
The essential oils from the leaves of Annona pickelii and Annona salzmannii (Annonaceae) were obtained by hydrodistillation using a Clevenger apparatus, and analysed by GC-MS and GC-FID. A total of 21 compounds were identified in the essential oil of A. pickelii and 23 in that of A. salzmannii; sesquiterpenes predominated in both essential oils. Bicyclogermacrene (38.0%), (E)-caryophyllene (27.8%), α-copaene (6.9%) and α-humulene (4.0%) were the main components of A. pickelii, while δ-cadinene (22.6%), (E)-caryophyllene (21.4%), α-copaene (13.3%), bicyclogermacrene (11.3%) and germacrene D (6.9%) were the main components of A. salzmannii. The biological activities of the essential oils against Trypanosoma cruzi epimastigote forms and cytotoxicity against tumour cell lines (antitumour) were investigated. The essential oils showed potent trypanocidal and antitumour activities with values of IC50 lower than 100 µg mL(-1).
从番荔枝属（番荔枝科）的叶中通过水蒸气蒸馏法使用克利夫兰挥发油收集器提取精油，并通过 GC-MS 和 GC-FID 进行分析。在 A. pickelii 的精油中鉴定出了 21 种化合物，在 A. salzmannii 的精油中鉴定出了 23 种化合物；两种精油中都以倍半萜为主。双环大根香叶烯（38.0%）、（E）-石竹烯（27.8%）、α-古巴烯（6.9%）和α-葎草烯（4.0%）是 A. pickelii 的主要成分，而δ-杜松烯（22.6%）、（E）-石竹烯（21.4%）、α-古巴烯（13.3%）、双环大根香叶烯（11.3%）和大根香叶二烯（6.9%）是 A. salzmannii 的主要成分。研究了精油对克氏锥虫滋养体形式的生物活性和对肿瘤细胞系的细胞毒性（抗肿瘤）。这些精油具有很强的杀锥虫活性和抗肿瘤活性，IC50 值低于 100μg·mL-1。
