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1
The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis.色甘酸钠和酮替芬对肥大细胞增多症患者尿中组胺及N-τ-甲基咪唑乙酸排泄的影响
Br J Clin Pharmacol. 1989 Jan;27(1):88-91. doi: 10.1111/j.1365-2125.1989.tb05339.x.
2
Oral disodium cromoglycate in mastocytosis.
Acta Derm Venereol. 1981;61(3):272-3.
3
Long-term modification on histamine-induced bronchoconstriction by disodium cromoglycate and ketotifen versus placebo.色甘酸钠和酮替芬与安慰剂对组胺诱导的支气管收缩的长期影响。
Allergy. 1985 May;40(4):242-9. doi: 10.1111/j.1398-9995.1985.tb00228.x.
4
A double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis.
J Allergy Clin Immunol. 1989 May;83(5):866-70. doi: 10.1016/0091-6749(89)90097-3.
5
[Comparative evaluation of the effectiveness of sodium cromoglycate and ketotifen in bronchial asthma and their effect on blood histamine and polymyxin-induced bronchial spasm].色甘酸钠与酮替芬治疗支气管哮喘的疗效比较及其对血液组胺和多粘菌素诱导的支气管痉挛的影响
Pneumonol Pol. 1983 Nov;51(11):547-51.
6
[Prophylaxis of bronchial asthma--disodium cromoglycate and ketotifen].支气管哮喘的预防——色甘酸钠与酮替芬
Harefuah. 1987 May 1;112(9):462-6.
7
A comparison of the inhibitory effects of ketotifen and disodium cromoglycate on bronchial responses to house dust, with special reference to the late asthmatic response.酮替芬与色甘酸钠对支气管对屋尘反应的抑制作用比较，特别提及迟发性哮喘反应。
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A double-blind trial comparing disodium cromoglycate (DSCG), and ketotifen in extrinsic asthmatic children.一项比较色甘酸钠（DSCG）和酮替芬对过敏性哮喘儿童疗效的双盲试验。
Clin Allergy. 1981 Jul;11(4):401-5. doi: 10.1111/j.1365-2222.1981.tb01611.x.
9
Antigen bronchial challenge and efficacy after 4 weeks of treatment with ketotifen and disodium cromoglycate.用酮替芬和色甘酸钠治疗4周后的抗原支气管激发试验及疗效
Respiration. 1983;44(2):103-8. doi: 10.1159/000194535.
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Comparison of the protective effect of ketotifen and disodium cromoglycate on exercise-induced asthma in asthmatic boys.
Allergy. 1983 Jan;38(1):31-5. doi: 10.1111/j.1398-9995.1983.tb00853.x.

引用本文的文献

1
Pharmacological treatment options for mast cell activation disease.肥大细胞活化疾病的药物治疗选择
Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul;389(7):671-94. doi: 10.1007/s00210-016-1247-1. Epub 2016 Apr 30.
2
Mastocytosis: update on pharmacotherapy and future directions.肥大细胞增多症：药物治疗的最新进展和未来方向。
Expert Opin Pharmacother. 2013 Oct;14(15):2033-45. doi: 10.1517/14656566.2013.824424.
3
Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders.

本文引用的文献

1
Ketotifen: current views on its mechanism of action and their therapeutic implications.酮替芬：关于其作用机制及其治疗意义的当前观点。
Respiration. 1984;45(4):411-21. doi: 10.1159/000194648.
2
Increased production of prostaglandin D2 in patients with systemic mastocytosis.系统性肥大细胞增多症患者中前列腺素D2的产生增加。
N Engl J Med. 1980 Dec 11;303(24):1400-4. doi: 10.1056/NEJM198012113032405.
3
Factitious wealing at the site of previous cutaneous response.先前皮肤反应部位的人工性风团。
酮替芬。对其药效学和药代动力学特性以及在哮喘和过敏性疾病中的治疗用途的综述。
Drugs. 1990 Sep;40(3):412-48. doi: 10.2165/00003495-199040030-00006.
Br J Dermatol. 1969 Dec;81(12):882-4. doi: 10.1111/j.1365-2133.1969.tb15968.x.
4
Comparative evaluation of the radioenzymatic method for the determination of urinary histamine with a mass spectrometric assay.用于测定尿组胺的放射酶法与质谱分析法的比较评估。
J Chromatogr. 1985 Feb 27;338(1):41-9. doi: 10.1016/0378-4347(85)80068-2.
5
Comparison of the therapeutic efficacy of cromolyn sodium with that of combined chlorpheniramine and cimetidine in systemic mastocytosis. Results of a double-blind clinical trial.色甘酸钠与氯苯那敏联合西咪替丁治疗系统性肥大细胞增多症的疗效比较。一项双盲临床试验的结果
Am J Med. 1985 Jan;78(1):9-14. doi: 10.1016/0002-9343(85)90454-1.
6
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.类胰蛋白酶水平作为全身过敏反应和肥大细胞增多症中肥大细胞活化的指标。
N Engl J Med. 1987 Jun 25;316(26):1622-6. doi: 10.1056/NEJM198706253162603.
7
Prostaglandin D2 and histamine release in cold urticaria.
J Allergy Clin Immunol. 1986 Sep;78(3 Pt 1):458-61. doi: 10.1016/0091-6749(86)90033-3.
8
Prevention of mast-cell degranulation by ketotifen in patients with physical urticarias.酮替芬对物理性荨麻疹患者肥大细胞脱颗粒的预防作用。
Ann Intern Med. 1986 Apr;104(4):507-10. doi: 10.7326/0003-4819-104-4-507.
9
Association of platelet-activating factor with primary acquired cold urticaria.
N Engl J Med. 1985 Aug 15;313(7):405-9. doi: 10.1056/NEJM198508153130702.
10
Oral disodium cromoglycate in the treatment of systemic mastocytosis.
N Engl J Med. 1979 Aug 30;301(9):465-9. doi: 10.1056/NEJM197908303010903.

色甘酸钠和酮替芬对肥大细胞增多症患者尿中组胺及N-τ-甲基咪唑乙酸排泄的影响

The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis.

作者信息

Mallet A I, Norris P, Rendell N B, Wong E, Greaves M W

机构信息

Institute of Dermatology, St Thomas' Hospital, United Medical School, London.

出版信息

Br J Clin Pharmacol. 1989 Jan;27(1):88-91. doi: 10.1111/j.1365-2125.1989.tb05339.x.

DOI:10.1111/j.1365-2125.1989.tb05339.x
PMID:2495814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1379709/
Abstract

Treatment of four mastocytosis patients with the mast cell stabilising drugs, disodium cromoglycate and ketotifen failed to alter significantly the urinary excretion levels of histamine or N tau-methylimidazole acetic acid. No clinical improvement was noted in any subject after treatment by either drug.

摘要

用肥大细胞稳定剂色甘酸二钠和酮替芬治疗4例肥大细胞增多症患者，并未显著改变组胺或N-τ-甲基咪唑乙酸的尿排泄水平。两种药物治疗后，任何受试者均未观察到临床改善。