Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
J Cell Biol. 2014 Jun 23;205(6):759-69. doi: 10.1083/jcb.201401126.
Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport.
两个细胞器之间紧密相邻的区域，通常被称为膜接触位点（MCS），大多形成于内质网和另一个细胞器之间，尽管线粒体和其他细胞器之间的接触也已开始被描述。虽然这些接触位点自从细胞首次被电子显微镜观察到以来就已经被注意到，但这些区域的大多数功能在很长一段时间内仍然不清楚。在过去的几年中，我们对 MCS 的理解有了显著的提高，揭示了它们在细胞内信号转导、代谢、代谢物运输以及细胞器遗传、分裂和运输中的关键作用。
