Tong Liping, Wang Yong, Zhou Yongan, Zheng Xiaoqing, Liu Honggang, Sun Jianyong, Li Xiaofei, Yan Xiaolong
Department of Thoracic Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.
Department of General Surgery, Weinan Center Hospital, Weinan, Shaanxi 714000, P.R. China.
Oncol Lett. 2014 Jul;8(1):72-76. doi: 10.3892/ol.2014.2069. Epub 2014 Apr 15.
Malignant fibrous histiocytoma (MFH) is rare in the chest wall, particularly in patients who have undergone radiotherapy for primary nasopharyngeal cancer. In the present study, a case of MFH of the upper chest wall that appeared four years after initial radiotherapy for squamous cell carcinoma of the nasopharynx is reported. Furthermore, two-step surgical management was successfully performed consisting of i) tumor-reductive excision and ii) limb salvage surgery, including wide resection of the tumor mass, defect reconstruction of the chest wall using left latissimus dorsi myocutaneous flap and dermatoplasty of the flap-supplied region. The progress of the clinical characteristics, the reasons for radiation-induced carcinogenesis, the treatment options and the prognostic factors of MFH are also reviewed. Finally, the importance of prevention and follow-up of this malignancy are highlighted and specific advice is offered.
恶性纤维组织细胞瘤（MFH）在胸壁中较为罕见，尤其是在接受过原发性鼻咽癌放疗的患者中。在本研究中，报告了一例在上颌窦鳞状细胞癌初次放疗四年后出现的上胸壁MFH病例。此外，成功实施了两步手术治疗，包括：i）肿瘤减瘤切除术；ii）保肢手术，包括广泛切除肿瘤块、使用左背阔肌肌皮瓣重建胸壁缺损以及对皮瓣供区进行植皮。还回顾了MFH的临床特征进展、辐射致癌的原因、治疗选择和预后因素。最后，强调了对这种恶性肿瘤进行预防和随访的重要性并提供了具体建议。
