Pryczynicz Anna, Bandurski Roman, Guzińska-Ustymowicz Katarzyna, Niewiarowska Katarzyna, Kemona Andrzej, Kędra Bogusław
Department of General Pathomorphology, The Medical University of Białystok, Białystok 15-269, Poland.
The Second Department of General and Gastroenterological Surgery, The Medical University of Białystok, Białystok 15-269, Poland.
Oncol Lett. 2014 Jul;8(1):441-445. doi: 10.3892/ol.2014.2141. Epub 2014 May 13.
Ménétrier's disease (MD) is a rare type of hypertrophic gastropathy involving the body of the stomach, which is characterized by thickening of the mucous membrane in the form of giant rugal folds, hypochlorhydria and protein loss. The potential for malignant transformation of this lesion remains a controversial topic. Therefore, in the present study, a case of a 51-year-old male exhibiting MD with coexisting advanced gastric cancer is described; a review of the literature is also presented. The present case emphasized that MD requires particular attention and should be regarded as a premalignant condition due to the previously documented cases of its coexistence with gastric cancer, in addition to the lack of knowledge regarding its pathogenesis and effective therapeutic management.
梅内特里尔病（MD）是一种罕见的肥厚性胃病，累及胃体，其特征为胃黏膜以巨大皱襞的形式增厚、胃酸分泌减少和蛋白质丢失。这种病变的恶性转化可能性仍然是一个有争议的话题。因此，在本研究中，描述了一例51岁男性患有MD并伴有晚期胃癌的病例；同时也对文献进行了综述。本病例强调，由于之前有MD与胃癌共存的病例记录，以及对其发病机制和有效治疗管理缺乏了解，MD需要特别关注，应被视为一种癌前状态。
