Schaumann B A, Winge V B, Garry V F
Research Service, Veterans Administration Medical Center, Minneapolis, MN 55417.
Epilepsy Res. 1989 Mar-Apr;3(2):182-4. doi: 10.1016/0920-1211(89)90048-x.
Sister chromatid exchanges (SCE) were studied in peripheral lymphocyte cultures of 13 adult male patients with epilepsy treated chronically with valproate (VPA) and in their matched controls. No statistically significant differences in SCE level were found between the patient and control groups, indicating a lack of mutagenic potential of VPA within the therapeutic dose range.
对13例长期接受丙戊酸盐（VPA）治疗的成年男性癫痫患者及其匹配对照的外周血淋巴细胞培养物进行了姐妹染色单体交换（SCE）研究。患者组和对照组之间的SCE水平未发现统计学上的显著差异，表明在治疗剂量范围内VPA缺乏诱变潜力。
