Schaumann B, Johnson S B, Wang N, Van Brunt S
Environ Mutagen. 1985;7(5):711-4. doi: 10.1002/em.2860070509.
Sister chromatid exchanges (SCE) were studied in lymphocyte cultures of 12 adult male epileptic patients on long-term monotherapy with phenytoin (PHT) and of matched controls. Significantly increased frequency of SCE was observed in the epileptic patients as a group and in almost all individuals, indicating a detectable chromosome damaging effect of PHT therapy on its human users.
对12名长期接受苯妥英（PHT）单一疗法治疗的成年男性癫痫患者以及相匹配的对照者的淋巴细胞培养物进行了姐妹染色单体交换（SCE）研究。作为一个群体，癫痫患者以及几乎所有个体的SCE频率均显著增加，这表明PHT疗法对其使用者具有可检测到的染色体损伤作用。
