Jameel Mohammad, Ali Abuzer, Ali Mohammed
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Phytochemistry Research Laboratory, Jamia Hamdard, New Delhi, India.
J Adv Pharm Technol Res. 2014 Apr;5(2):64-9. doi: 10.4103/2231-4040.133424.
Fumaria parviflora Lam. (Fumariaceae) is an annual herb found throughout the world. Traditionally it has great significance in various disorders. In folk medicine of Turkey it is used against hepato-biliary dysfunction and imported from Iran. In Charaka and Sushruta, it is recommended for treatment of fevers, blood disorders, chronic skin diseases, urinary diseases and cough. The compounds were isolated from methanolic extract of the plants by column chromatography using silica gel (60-120 mesh) as stationary phase and structure of the isolated compounds have been established on the basis of spectral data analysis and chemical reactions. Phytochemical investigation of its aerial parts led to the isolation of five new compounds characterized as (5αH,11αH)-8-oxo-homoiridolide (1), n-docosanyl-2-O-β-D-glucopyranosyl salicylate (2), 2-methyl-6-hydroxymethylenedodecan-10-oyl-12, 15-olide14-O-β-D-xylopyranoside (3), 4-oxo-stigmast-5-en-3β-ol-D-glucopyranoside (4) and salicylic acid-O-β-D-xylopyranoside (5) along with the known compounds α-D-glucopyranosyl hexadecanoate (6) and α-D-glucopyranosyl- (2 → 1')-α-D-glucopyranoside (7). The isolated compounds are useful as they will provide essential data and information for the further researchers and development of effective analytical marker for identity, purity and quality control of this traditional plant in future.
小花烟堇(紫堇科)是一种一年生草本植物,遍布世界各地。传统上,它在治疗各种疾病方面具有重要意义。在土耳其民间医学中,它被用于治疗肝胆功能障碍,并且是从伊朗进口的。在《阇罗迦集》和《妙闻集》中,它被推荐用于治疗发烧、血液疾病、慢性皮肤病、泌尿系统疾病和咳嗽。通过以硅胶(60 - 120目)为固定相的柱色谱法从植物的甲醇提取物中分离出这些化合物,并基于光谱数据分析和化学反应确定了分离出的化合物的结构。对其地上部分的植物化学研究导致分离出五种新化合物,分别为(5αH,11αH)-8-氧代高环烯醚萜内酯(1)、正二十二烷基-2-O-β-D-吡喃葡萄糖基水杨酸酯(2)、2-甲基-6-羟基亚甲基十二烷-10-酰基-12,15-内酯-14-O-β-D-吡喃木糖苷(3)、4-氧代-豆甾-5-烯-3β-醇-D-吡喃葡萄糖苷(4)和水杨酸-O-β-D-吡喃木糖苷(5),以及已知化合物α-D-吡喃葡萄糖基十六烷酸酯(6)和α-D-吡喃葡萄糖基-(2→1')-α-D-吡喃葡萄糖苷(7)。这些分离出的化合物很有用,因为它们将为进一步的研究人员提供重要数据和信息,并为未来这种传统植物的身份鉴定、纯度和质量控制开发有效的分析标记。