Rossini P M, Zarola F, Floris R, Bernardi G, Perretti A, Pelosi L, Caruso G, Caramia M D
Department of Public Health, Second University of Rome Tor Vergata, Italy.
Eur Neurol. 1989;29(1):41-7. doi: 10.1159/000116376.
In order to define the most suitable instrumental protocol for the diagnosis of multiple sclerosis (MS), 41 patients with definite (D = 14), probable (P = 14) and suspected (S = 13) MS were examined with CSF immunology, brain MRI and multimodal evoked potentials. The central motor tracts were also tested. The following alteration rates were found: MRI = 78%, CSF = 63.6%, VEP = 70.0%, median nerve SEP = 50%, peroneal nerve SEP = 68.0%, BAEPs = 35.7%, motor-evoked potentials (MEPs) = 74.0%. Altogether, EPs were abnormal in 90% of cases. Normal MRI with altered EPs were found in 22% of cases, whilst a normal EP battery with defective CSF or MRI findings were found in 7%. Twenty-six out of 27 patients with P or S forms were reclassified into a D one when considering EPs and MRI features.
为确定诊断多发性硬化症（MS）最合适的检测方案，对41例确诊（D = 14）、疑似（P = 14）和可能（S = 13）MS患者进行了脑脊液免疫学、脑部MRI及多模式诱发电位检查。同时对中枢运动神经束进行了检测。发现以下异常率：MRI = 78%，脑脊液 = 63.6%，视觉诱发电位（VEP）= 70.0%，正中神经体感诱发电位（SEP）= 50%，腓总神经SEP = 68.0%，脑干听觉诱发电位（BAEPs）= 35.7%，运动诱发电位（MEPs）= 74.0%。总体而言，90%的病例诱发电位异常。22%的病例MRI正常但诱发电位异常，而7%的病例诱发电位正常但脑脊液或MRI检查结果有缺陷。在考虑诱发电位和MRI特征时，27例疑似或可能MS的患者中有26例被重新分类为确诊病例。
