Cannas Sara, Molicotti Paola, Usai Donatella, Maxia Andrea, Zanetti Stefania
a Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche , Università degli Studi di Sassari , Viale San Pietro 43/b, 07100 Sassari , Italy.
Nat Prod Res. 2014;28(23):2173-7. doi: 10.1080/14786419.2014.925892. Epub 2014 Jun 24.
Candida species belong to the normal microbiota of the oral cavity, gastrointestinal tract and vagina. The increasing incidence of drug-resistant pathogens and the toxicity of the antifungal compounds have drawn the attention towards the antimicrobial activity of natural products, an inexpensive alternative. The aim of this work was to evaluate the adhesion activity, the biofilm formation and the action of the Myrtus communis L. essential oil (EO) on the biofilm formation towards three species isolated from clinical samples: Candida albicans, Candida parapsilosis and Candida tropicalis. Furthermore, we evaluated the antimycotic activity of the EO towards the three species, and the results were compared with the minimum inhibitory concentration of six antimycotics. The activity of the EO against C. albicans and C. parapsilosis was better than that obtained against C. tropicalis; moreover, the strains used in the assay were adhesive and biofilm producer, and the effect of myrtle EO on the biofilm formation yielded encouraging results.
念珠菌属属于口腔、胃肠道和阴道的正常微生物群。耐药病原体发病率的上升以及抗真菌化合物的毒性，使得人们将注意力转向天然产物的抗菌活性，这是一种廉价的替代方案。这项工作的目的是评估香桃木精油（EO）对从临床样本中分离出的三种念珠菌（白色念珠菌、近平滑念珠菌和热带念珠菌）的黏附活性、生物膜形成以及对生物膜形成的作用。此外，我们评估了该精油对这三种念珠菌的抗真菌活性，并将结果与六种抗真菌药物的最低抑菌浓度进行了比较。该精油对白色念珠菌和平滑念珠菌的活性优于对热带念珠菌的活性；此外，试验中使用的菌株具有黏附性且能产生生物膜，香桃木精油对生物膜形成的影响产生了令人鼓舞的结果。
