Theodoropoulos George E, Karantanos Theodoros
Colorectal Unit, First Department of Propaedeutic Surgery, Athens Medical School, 7 Semitelou Street, GR-11528 Athens, Greece.
Colorectal Unit, First Department of Propaedeutic Surgery, Athens Medical School, Athens, Greece.
JSLS. 2014 Apr-Jun;18(2):225-35. doi: 10.4293/108680813X13753907291152.
This review focuses on health-related quality-of-life (HRQoL) assessment questionnaires and the influence of various parameters on HRQoL at distinct time points after laparoscopic colectomy for cancer.
A PubMed electronic database literature search was conducted.
Twenty studies (7 prospective randomized, 5 nonrandomized, 2 retrospective, 1 matched, and 3 observational studies) used the following HRQoL tools: European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30 (8 studies), EORTC QLQ-CR38 (6 studies), EORTC QLQ-CR29 (1 study), Short Form 36 (8 studies), Gastrointestinal Quality Life Index (2 studies), EuroQoL-5D (1 study), Symptoms Distress Scale (2 studies), Quality of Life Index (2 studies), and global quality of life (1 study). Long-term beneficial effects on patient HRQoL after laparoscopic colectomy for cancer have not been clearly shown compared with "open" resections. A physical function deterioration and emotional function improvement are observed during the first month. Most patients have recovered at 12 months. Distinct HRQoL domains may be affected in older, female, and chemotherapy-treated patients. HRQoL-related parameters of pain and cosmesis have been assessed in few of the current studies on hand-assisted and single-incision laparoscopic colectomy.
Studies' heterogeneity in terms of assessment tools and time points remains as the main obstacle to establish robust conclusions. The addition of more patients and extension of the follow-up period will improve our knowledge on HRQoL changes after laparoscopic colectomy for cancer.
本综述聚焦于与健康相关的生活质量（HRQoL）评估问卷，以及在腹腔镜结肠癌切除术后不同时间点各种参数对HRQoL的影响。
进行了PubMed电子数据库文献检索。
20项研究（7项前瞻性随机研究、5项非随机研究、2项回顾性研究、1项匹配研究和3项观察性研究）使用了以下HRQoL工具：欧洲癌症研究与治疗组织（EORTC）生活质量问卷（QLQ）-C30（8项研究）、EORTC QLQ-CR38（6项研究）、EORTC QLQ-CR29（1项研究）、简明健康调查问卷（Short Form 36）（8项研究）、胃肠道生活质量指数（2项研究）、欧洲五维健康量表（EuroQoL-5D）（1项研究）、症状困扰量表（2项研究）、生活质量指数（2项研究）以及总体生活质量（1项研究）。与“开放”切除术相比，腹腔镜结肠癌切除术后对患者HRQoL的长期有益影响尚未明确显现。在第一个月观察到身体功能恶化和情绪功能改善。大多数患者在12个月时恢复。年龄较大、女性以及接受化疗的患者中，不同的HRQoL领域可能会受到影响。在目前关于手辅助和单切口腹腔镜结肠癌切除术的少数研究中，对与HRQoL相关的疼痛和美观参数进行了评估。
研究在评估工具和时间点方面的异质性仍然是得出可靠结论的主要障碍。增加更多患者并延长随访期将提高我们对腹腔镜结肠癌切除术后HRQoL变化的认识。
