Adak Avijit K, Lin Hong-Jyune, Lin Chun-Cheng
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
Org Biomol Chem. 2014 Aug 14;12(30):5563-73. doi: 10.1039/c4ob00827h. Epub 2014 Jun 25.
Carbohydrates are essential mediators of many important extracellular binding events. Multivalent effects are often required for these binding interactions that are generally weak. Biologically significant carbohydrate-modified nanomaterials are an appealing model system for a systematic investigation of multivalent binding effects. This review seeks to highlight recent striking examples of multivalent glycosylated nanomaterials concentrating on carbohydrate-protein interactions. The specific aim is to provide an overview of various aspects of glyco-nanoparticles in binding assays, targeted therapy, molecular imaging, enzyme activity assay, and bacterium detection.
碳水化合物是许多重要细胞外结合事件的关键介质。这些通常较弱的结合相互作用往往需要多价效应。具有生物学意义的碳水化合物修饰纳米材料是系统研究多价结合效应的一个有吸引力的模型系统。本综述旨在重点介绍多价糖基化纳米材料的最新显著实例，重点关注碳水化合物 - 蛋白质相互作用。具体目标是概述糖纳米颗粒在结合测定、靶向治疗、分子成像、酶活性测定和细菌检测等各个方面的情况。
